Seroprevalence of Infection in Patients with Hyperlipidemia: A Case-Control Study

Overview

Journal Iran J Parasitol

Publisher Tehran University of Medical Sciences

Specialty Parasitology

Date 2024 Sep 25

PMID 39318812

Authors

Mohammad Amin Sari

Paridokht Karimian

Eshrat Beigom Kia

Mehdi Mohebali

Amirhossin Aghakhani

Enayat Darabi

Zohre Fakhrieh-Kashan

Affiliations

Soon will be listed here.

Abstract

Background: is one of the soil-transmitted helminths (STH) in tropical and subtropical regions. The role of lipid profile has been investigated in the survival of larval stages of helminths, but there is limited information about the role of lipid profiles and strongyloidiasis. Hence, we aimed to investigate the seroprevalence of infection in patients with hyperlipidemia is compared with the nonhyperlipidemia.

Methods: In 2023, participants were selected from the laboratory of Porsina Hospital in Guilan Province, northern Iran and their lipid profiles including TG, CHOL, LDL, HDL, and VLDL were measured. They were divided into two groups of case and control and matched based on sex and age. Ab (IgG) was measured by ELISA methods, using the NovaTec kit. Finally, statistical analysis was performed.

Results: Each case and control group consisted of 105 participants, from 13 to 80 years old. 56.66% were female and 43.33% were male. The seroprevalence of was found 4.76% in the case group compared to 0.95% in the control group. We found an association between TG fall and VLDL with seroprevalence of in hyperlipidemia group (= 0.034), but other lipid profiles did not show a significant association. A significant relationship was found between contact with dogs and seroprevalence of (=0.001).

Conclusion: The seroprevalence of in the case group was 5 times higher than the control group. A significant association between TG and VLDL fall with Ab (IgG) was observed, but future studies with more sample sizes are suggested to investigate the anti-atherogenic effect of . Also, a genetic assessment of and the host (humane and dogs) is recommended to research zoonotic potential in epidemic areas.

References

Schar F, Trostdorf U, Giardina F, Khieu V, Muth S, Marti H . Strongyloides stercoralis: Global Distribution and Risk Factors. PLoS Negl Trop Dis. 2013; 7(7):e2288. PMC: 3708837. DOI: 10.1371/journal.pntd.0002288. View

Ines E, Sampaio Silva M, de Souza J, Alcantara Galvao A, Teixeira M, Soares N . Alterations in serum paraoxonase-1 activity and lipid profile in chronic alcoholic patients infected with Strongyloides stercoralis. Acta Trop. 2016; 166:1-6. DOI: 10.1016/j.actatropica.2016.10.013. View

Doenhoff M, Stanley R, Griffiths K, Jackson C . An anti-atherogenic effect of Schistosoma mansoni infections in mice associated with a parasite-induced lowering of blood total cholesterol. Parasitology. 2002; 125(Pt 5):415-21. DOI: 10.1017/s0031182002002275. View

Rafiei R, Rafiei A, Rahdar M, Keikhaie B . Seroepidemiology of amongst immunocompromised patients in Southwest Iran. Parasite Epidemiol Control. 2018; 1(3):229-232. PMC: 5991854. DOI: 10.1016/j.parepi.2016.08.001. View

Varzegar P, Bayani M, Kalantari N, Nasiri-Kenari M, Amini Navaie B, Mollalo A . Seroprevalence of among patients with leptospirosis in northern Iran: a descriptive cross-sectional study. J Helminthol. 2021; 95:e34. DOI: 10.1017/S0022149X21000237. View

Sharifdini M, Kia E, Ashrafi K, Hosseini M, Mirhendi H, Mohebali M . An Analysis of Clinical Characteristics of Strongyloides stercoralis in 70 indigenous patients in Iran. Iran J Parasitol. 2015; 9(2):155-62. PMC: 4386034. View

Ramos T, de Vasconcelos A, de Carvalho V, Lima V . [Alterations in cholesterol, triglyceride and total phospholipid levels in plasma of Callithrix jacchus (sagüi) reinfected by Schistosoma mansoni]. Rev Soc Bras Med Trop. 2004; 37(1):37-40. DOI: 10.1590/s0037-86822004000100010. View

Linstead D . New defined and semi-defined media for cultivation of the flagellate Trichomonas vaginalis. Parasitology. 1981; 83(Pt 1):125-37. DOI: 10.1017/s0031182000050101. View

Ashiri A, Rafiei A, Beiromvand M, Khanzadeh A, Alghasi A . Screening of Strongyloides stercoralis infection in high-risk patients in Khuzestan Province, Southwestern Iran. Parasit Vectors. 2021; 14(1):37. PMC: 7796600. DOI: 10.1186/s13071-020-04549-6. View

10.

Wiedermann U, Stemberger H, Unfried E, Widhalm K, Kundi M, Altenriederer M . Intestinal worm burden and serum cholesterol or lipid concentration in a Shipibo population (Peru). Zentralbl Bakteriol. 1991; 275(2):279-86. DOI: 10.1016/s0934-8840(11)80077-0. View

11.

Huang J, Zhang H, Liu S, Wang M, Wan B, Velani B . Is Toxoplasma gondii infection correlated with nonalcoholic fatty liver disease?- a population-based study. BMC Infect Dis. 2018; 18(1):629. PMC: 6282358. DOI: 10.1186/s12879-018-3547-1. View

12.

Carvalho E, Da Fonseca Porto A . Epidemiological and clinical interaction between HTLV-1 and Strongyloides stercoralis. Parasite Immunol. 2005; 26(11-12):487-97. DOI: 10.1111/j.0141-9838.2004.00726.x. View

13.

Nutman T . Human infection with Strongyloides stercoralis and other related Strongyloides species. Parasitology. 2016; 144(3):263-273. PMC: 5563389. DOI: 10.1017/S0031182016000834. View

14.

Montresor A, Mupfasoni D, Mikhailov A, Mwinzi P, Lucianez A, Jamsheed M . The global progress of soil-transmitted helminthiases control in 2020 and World Health Organization targets for 2030. PLoS Negl Trop Dis. 2020; 14(8):e0008505. PMC: 7446869. DOI: 10.1371/journal.pntd.0008505. View

15.

Sharifdini M, Ghanbarzadeh L, Barikani A, Saraei M . Prevalence of Intestinal Parasites among Rural Inhabitants of Fouman, Guilan Province, Northern Iran with Emphasis on . Iran J Parasitol. 2020; 15(1):91-100. PMC: 7244841. View

16.

Shepherd J . Lipids in health and disease. Biochem Soc Trans. 2004; 32(Pt 6):1051-6. DOI: 10.1042/BST0321051. View

17.

Simons K, Toomre D . Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2001; 1(1):31-9. DOI: 10.1038/35036052. View

18.

Mido S, Fath E, Farid A, Nonaka N, Oku Y, Horii Y . Trichinella spiralis: infection changes serum paraoxonase-1 levels, lipid profile, and oxidative status in rats. Exp Parasitol. 2012; 131(2):190-4. DOI: 10.1016/j.exppara.2012.03.023. View

19.

Marchi Blatt J, Cantos G . Evaluation of techniques for the diagnosis of Strongyloides stercoralis in human immunodeficiency virus (HIV) positive and HIV negative individuals in the city of Itajaí, Brazil. Braz J Infect Dis. 2003; 7(6):402-8. DOI: 10.1590/s1413-86702003000600008. View

20.

Fan W, Fu Q, Yu Y . Pulmonary strongyloidiasis and hyperinfection in a Patient with idiopathic inflammatory myopathy：A case report. Heliyon. 2023; 10(1):e23484. PMC: 10750171. DOI: 10.1016/j.heliyon.2023.e23484. View