Latent Profiles of Global Electrical Heterogeneity: the Hispanic Community Health Study/Study of Latinos

Overview

Journal Eur Heart J Digit Health

Publisher Oxford University Press

Specialty Cardiology & Vascular Diseases

Date 2024 Sep 25

PMID 39318685

Authors

Larisa G Tereshchenko

Kazi T Haq

Stacey J Howell

Evan C Mitchell

Jesus Martinez

Jessica Hyde

Genesis Briceno

Jose Pena

Edvinas Pocius

Akram Khan

Elsayed Z Soliman

Joao A C Lima

Samir R Kapadia

Anita D Misra-Hebert

Michael W Kattan

Mayank M Kansal

Martha L Daviglus

Robert Kaplan

Affiliations

Soon will be listed here.

Abstract

Aims: Despite the highest prevalence of stroke, obesity, and diabetes across races/ethnicities, paradoxically, Hispanic/Latino populations have the lowest prevalence of atrial fibrillation and major Minnesota code-defined ECG abnormalities. We aimed to use Latent Profile Analysis in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) population to obtain insight into epidemiological discrepancies.

Methods And Results: We conducted a cross-sectional analysis of baseline HCHS/SOL visit. Global electrical heterogeneity (GEH) was measured as spatial QRS-T angle (QRSTa), spatial ventricular gradient azimuth (SVGaz), elevation (SVGel), magnitude (SVGmag), and sum absolute QRST integral (SAIQRST). Statistical analysis accounted for the stratified two-stage area probability sample design. We fitted a multivariate latent profile generalized structural equation model adjusted for age, sex, ethnic background, education, hypertension, diabetes, smoking, dyslipidaemia, obesity, chronic kidney disease, physical activity, diet quality, average RR' interval, median beat type, and cardiovascular disease (CVD) to gain insight into the GEH profiles. Among 15 684 participants (age 41 years; 53% females; 6% known CVD), 17% had an increased probability of likely abnormal GEH profile (QRSTa 80 ± 27°, SVGaz -4 ± 21°, SVGel 72 ± 12°, SVGmag 45 ± 12 mVms, and SAIQRST 120 ± 23 mVms). There was a 23% probability for a participant of being in Class 1 with a narrow QRSTa (40.0 ± 10.2°) and large SVG (SVGmag 108.3 ± 22.6 mVms; SAIQRST 203.4 ± 39.1 mVms) and a 60% probability of being in intermediate Class 2.

Conclusion: A substantial proportion (17%) in the Hispanic/Latino population had an increased probability of altered, likely abnormal GEH profile, whereas 83% of the population was resilient to harmful risk factors exposures.

Citing Articles

Electrical Heterogeneity in Hispanic Background Subpopulations: The HCHS/SOL.

Tereshchenko L, Haq K, Howell S, Mitchell E, Hyde J, Martinez J JACC Adv. 2025; 3(12):101225.

PMID: 39817081 PMC: 11733965. DOI: 10.1016/j.jacadv.2024.101225.

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