A New Perspective on the Prediction and Treatment of Stroke: The Role of Uric Acid

Overview

Journal Neurosci Bull

Specialty Neurology

Date 2024 Sep 23

PMID 39312108

Authors

Bingrui Zhu

Xiaobin Huang

Jiahao Zhang

Xiaoyu Wang

Sixuan Tian

Tiantong Zhan

Yibo Liu

Haocheng Zhang

Sheng Chen

Cheng Yu

Affiliations

Soon will be listed here.

Abstract

Stroke, a major cerebrovascular disease, has high morbidity and mortality. Effective methods to reduce the risk and improve the prognosis are lacking. Currently, uric acid (UA) is associated with the pathological mechanism, prognosis, and therapy of stroke. UA plays pro/anti-oxidative and pro-inflammatory roles in vivo. The specific role of UA in stroke, which may have both neuroprotective and damaging effects, remains unclear. There is a U-shaped association between serum uric acid (SUA) levels and ischemic stroke (IS). UA therapy provides neuroprotection during reperfusion therapy for acute ischemic stroke (AIS). Urate-lowering therapy (ULT) plays a protective role in IS with hyperuricemia or gout. SUA levels are associated with the cerebrovascular injury mechanism, risk, and outcomes of hemorrhagic stroke. In this review, we summarize the current research on the role of UA in stroke, providing potential targets for its prediction and treatment.

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