Guanabenz Acetate, an Antihypertensive Drug Repurposed As an Inhibitor of Biofilm

Importance: Biofilm-associated bacterial infections are one of the major problems in medical settings. There are currently limited biofilm inhibitors available for clinical use. Guanabenz acetate, a drug used to treat high blood pressure, was found to be an effective anti-biofilm agent against . Our results show that this drug can inhibit the production of cellulose and curli amyloid protein, which are the two main components of biofilms. Our findings highlight the possibility of repurposing a drug to prevent biofilm formation.