Ethanol Inhibits the Activity of the B Form of Monoamine Oxidase in Human Platelet and Brain Tissue

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1985 Jan 1

PMID 3931139

Citations 3

Authors

B Tabakoff

J M Lee

P L Hoffman

Affiliations

Soon will be listed here.

Abstract

Ethanol selectively inhibits the activity of the B-form of monoamine oxidase (MAO) in membranes obtained from human platelet and brain. When endogenous concentrations of phenylethylamine are used as substrate, significant inhibition is induced by concentrations of ethanol that are attainable after ethanol ingestion (50 mM). The mechanism of ethanol's inhibition of MAO activity appears to involve perturbation of membrane lipids surrounding the enzyme.

Citing Articles

Monoamine oxidase gene transcription in human cell lines: treatment with psychoactive drugs and ethanol.

Ekblom J, Zhu Q, Chen K, Shih J J Neural Transm (Vienna). 1996; 103(6):681-92.

PMID: 8836930 DOI: 10.1007/BF01271228.

Effects of beta-phenylethylamine on locomotor activity, body temperature and ethanol blood concentrations during acute ethanol intoxication.

Aliyu S, Sewell R Psychopharmacology (Berl). 1987; 93(1):69-71.

PMID: 3114816 DOI: 10.1007/BF02439588.

Potentiation by deprenyl of the autoreceptor-mediated inhibition of [3H]-5-hydroxytryptamine release by 5-methoxytryptamine.

Galzin A, Langer S Naunyn Schmiedebergs Arch Pharmacol. 1986; 333(3):330-3.

PMID: 3093900 DOI: 10.1007/BF00512949.

References

WEINER N . Substrate specificity of brain amine oxidase of several mammals. Arch Biochem Biophys. 1960; 91:182-8. DOI: 10.1016/0003-9861(60)90487-2. View

Chordikian F, Tabakoff B, ALIVISATOS S . Ontogeny of multiple forms of monoamine oxidase in mouse brain. Brain Res. 1975; 93(2):301-8. DOI: 10.1016/0006-8993(75)90352-2. View

Kurosawa Y . Studies on monoamine oxidase. (Report XXV). Effects of alcohols on beef liver mitochondrial monoamine oxidase. Jpn J Pharmacol. 1974; 24(5):787-95. DOI: 10.1254/jjp.24.787. View

Houslay M, Tipton K . Rat liver mitochondrial monoamine oxidase. A change in the reaction mechanism on solubilization. Biochem J. 1975; 145(2):311-21. PMC: 1165220. DOI: 10.1042/bj1450311. View

MCEWEN Jr C, Sasaki G, Lenz Jr W . Human liver mitochondrial monoamine oxidase. I. Kinetic studies of model interactions. J Biol Chem. 1968; 243(20):5217-25. View

Heim F . [Effect of alcohols upon the enzymatic decomposition of tyramine]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1950; 210(1):16-22. View

Goridis C, Neff N . Evidence for a specific monoamine oxidase associated with sympathetic nerves. Neuropharmacology. 1971; 10(5):557-64. DOI: 10.1016/0028-3908(71)90021-9. View

Wurtman R, Axelrod J . A SENSITIVE AND SPECIFIC ASSAY FOR THE ESTIMATION OF MONOAMINE OXIDASE. Biochem Pharmacol. 1963; 12:1439-41. DOI: 10.1016/0006-2952(63)90215-6. View

Lyon R, McCOMB J, Schreurs J, Goldstein D . A relationship between alcohol intoxication and the disordering of brain membranes by a series of short-chain alcohols. J Pharmacol Exp Ther. 1981; 218(3):669-75. View

10.

Harris R, Schroeder F . Ethanol and the physical properties of brain membranes: fluorescence studies. Mol Pharmacol. 1981; 20(1):128-37. View

11.

GORKIN V, Romanova L . On the selective inhibition by some monoamine oxidase inhibitors of deamination of biogenic monoamines in vivo. Biochem Pharmacol. 1968; 17(6):855-60. DOI: 10.1016/0006-2952(68)90343-2. View

12.

Fowler C, Callingham B, Mantle T, Tipton K . The effect of lipophilic compounds upon the activity of rat liver mitochondrial monoamine oxidase-A and -B. Biochem Pharmacol. 1980; 29(8):1177-83. DOI: 10.1016/0006-2952(80)90414-1. View

13.

Tabakoff B, Anderson R, Ritzmann R . Brain acetaldehyde after ethanol administration. Biochem Pharmacol. 1976; 25(11):1305-9. DOI: 10.1016/0006-2952(76)90094-0. View

14.

Tabakoff B, Alivasatos S . Modified method for spectrophotometric determination of monoamine oxidase activity. Anal Chem. 1972; 44(2):427-8. DOI: 10.1021/ac60310a040. View

15.

Jain M . Monoamine oxidase: examination of multiple forms. Life Sci. 1977; 20(12):1925-33. DOI: 10.1016/0024-3205(77)90170-9. View

16.

Houslay M, Tipton K . Multiple forms of monoamine oxidase: fact and artefact. Life Sci. 1976; 19(4):467-77. DOI: 10.1016/0024-3205(76)90224-1. View

17.

Cook G, Otto D, Cornell N . Malonyl-CoA inhibition of carnitine palmitoyltransferase: interpretation of I50 and K1 values. Biochem J. 1983; 212(2):525-7. PMC: 1152077. DOI: 10.1042/bj2120525. View

18.

Karoum F, Speciale Jr S, Chuang L, Wyatt R . Selective effects of phenylethylamine on central catecholamines: a comparative study with amphetamine. J Pharmacol Exp Ther. 1982; 223(2):432-9. View

19.

Johnston J . Some observations upon a new inhibitor of monoamine oxidase in brain tissue. Biochem Pharmacol. 1968; 17(7):1285-97. DOI: 10.1016/0006-2952(68)90066-x. View

20.

Tabakoff B, Ritzmann R, Boggan W . Inhibtion of the transport of 5-hydroxyindoleacetic acid from brain by ethanol. J Neurochem. 1975; 24(5):1043-51. DOI: 10.1111/j.1471-4159.1975.tb03675.x. View