Colour Vision Changes Across Lifespan: Insights from FM100 and CAD Tests

Overview

Journal Vision (Basel)

Specialty Ophthalmology

Date 2024 Sep 23

PMID 39311321

Authors

Renars Truksa

Sergejs Fomins

Zane Jansone-Langina

Laura Tenisa

Affiliations

Soon will be listed here.

Abstract

(1) Background: in this research study, colour vision was evaluated in individuals aged 19 to 70 years with and without red-green colour vision disorders. (2) Methods: study participant colour vision was assessed with anomaloscope, HRR, FM100 hue, and CAD tests. (3) Results: No significant correlation was found between participant age and chromatic sensitivity of the red-green colour opponent channel. However, a decrease in blue-yellow colour opponent channel chromatic sensitivity was confirmed with the FM100 hue test and CAD test. Analysis of FM100 hue test error scores across age groups revealed a decline in chromatic sensitivity in the short-wave region of visible light with increasing age. Comparison of the colour-deficient individual results of the CAD and anomaloscope tests confirmed that CAD test sensitivity and specificity reaches 100%. However, some individuals with deutan-type deficits were misclassified as having protan-type deficits. This study confirmed the effectiveness of the FM100 test in identifying individuals with moderate to severe colour vision deficits, with sensitivity and specificity rates of 81.25% and 95.38%. (4) Conclusions: It was found that the FM100 hue test effectively identifies individuals with moderate and severe red-green colour vision deficiencies. On the other hand, individuals with mild colour vision deficiencies may go undetected with the FM100 hue test.

References

ONeill-Biba M, Sivaprasad S, Rodriguez-Carmona M, Wolf J, Barbur J . Loss of chromatic sensitivity in AMD and diabetes: a comparative study. Ophthalmic Physiol Opt. 2010; 30(5):705-16. DOI: 10.1111/j.1475-1313.2010.00775.x. View

Davidoff C, Neitz M, Neitz J . Genetic Testing as a New Standard for Clinical Diagnosis of Color Vision Deficiencies. Transl Vis Sci Technol. 2016; 5(5):2. PMC: 5017313. DOI: 10.1167/tvst.5.5.2. View

Bassi C, Galanis J, Hoffman J . Comparison of the Farnsworth-Munsell 100-Hue, the Farnsworth D-15, and the L'Anthony D-15 desaturated color tests. Arch Ophthalmol. 1993; 111(5):639-41. DOI: 10.1001/archopht.1993.01090050073032. View

Seshadri J, Christensen J, Lakshminarayanan V, Bassi C . Evaluation of the new web-based "Colour Assessment and Diagnosis" test. Optom Vis Sci. 2005; 82(10):882-5. DOI: 10.1097/01.opx.0000182211.48498.4e. View

Birch J . Worldwide prevalence of red-green color deficiency. J Opt Soc Am A Opt Image Sci Vis. 2012; 29(3):313-20. DOI: 10.1364/JOSAA.29.000313. View

Song H, Ping Chui T, Zhong Z, Elsner A, Burns S . Variation of cone photoreceptor packing density with retinal eccentricity and age. Invest Ophthalmol Vis Sci. 2011; 52(10):7376-84. PMC: 3183974. DOI: 10.1167/iovs.11-7199. View

Bailey J, Neitz M, Tait D, Neitz J . Evaluation of an updated HRR color vision test. Vis Neurosci. 2004; 21(3):431-6. DOI: 10.1017/s0952523804213463. View

Ao M, Li X, Qiu W, Hou Z, Su J, Wang W . The impact of age-related cataracts on colour perception, postoperative recovery and related spectra derived from test of hue perception. BMC Ophthalmol. 2019; 19(1):56. PMC: 6383292. DOI: 10.1186/s12886-019-1057-6. View

Pokorny J, Smith V, Lutze M . Aging of the human lens. Appl Opt. 2010; 26(8):1437-40. DOI: 10.1364/AO.26.001437. View

10.

Kinnear P . Proposals for scoring and assessing the 100-Hue test. Vision Res. 1970; 10(5):423-33. DOI: 10.1016/0042-6989(70)90123-9. View

11.

Bayer L, Funk J, Toteberg-Harms M . Incidence of dyschromatopsy in glaucoma. Int Ophthalmol. 2019; 40(3):597-605. DOI: 10.1007/s10792-019-01218-1. View

12.

Paramei G . Color discrimination across four life decades assessed by the Cambridge Colour Test. J Opt Soc Am A Opt Image Sci Vis. 2012; 29(2):A290-7. DOI: 10.1364/JOSAA.29.00A290. View

13.

Birch J . Identification of red-green colour deficiency: sensitivity of the Ishihara and American Optical Company (Hard, Rand and Rittler) pseudo-isochromatic plates to identify slight anomalous trichromatism. Ophthalmic Physiol Opt. 2010; 30(5):667-71. DOI: 10.1111/j.1475-1313.2010.00770.x. View

14.

Curcio C, Drucker D . Retinal ganglion cells in Alzheimer's disease and aging. Ann Neurol. 1993; 33(3):248-57. DOI: 10.1002/ana.410330305. View

15.

Xu J, Pokorny J, Smith V . Optical density of the human lens. J Opt Soc Am A Opt Image Sci Vis. 1997; 14(5):953-60. DOI: 10.1364/josaa.14.000953. View

16.

Rauscher F, Chisholm C, Edgar D, Barbur J . Assessment of novel binocular colour, motion and contrast tests in glaucoma. Cell Tissue Res. 2013; 353(2):297-310. DOI: 10.1007/s00441-013-1675-x. View

17.

Werner J, Steele V . Sensitivity of human foveal color mechanisms throughout the life span. J Opt Soc Am A. 1988; 5(12):2122-30. DOI: 10.1364/josaa.5.002122. View

18.

Paramei G, Oakley B . Variation of color discrimination across the life span. J Opt Soc Am A Opt Image Sci Vis. 2014; 31(4):A375-84. DOI: 10.1364/JOSAA.31.00A375. View

19.

Knoblauch K, Vital-Durand F, Barbur J . Variation of chromatic sensitivity across the life span. Vision Res. 2001; 41(1):23-36. DOI: 10.1016/s0042-6989(00)00205-4. View

20.

Weale R . Age and the transmittance of the human crystalline lens. J Physiol. 1988; 395:577-87. PMC: 1192010. DOI: 10.1113/jphysiol.1988.sp016935. View