Hyperbaric Oxygen Therapy Alleviates Intestinal Dysfunction Following Traumatic Brain Injury Via MA Regulation

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2024 Sep 23

PMID 39310263

Authors

Xuelai Yu

Wei Zhao

Yunyun Liu

Jingchuan Lv

Xiang Zhong

Peizan Huang

Affiliations

Soon will be listed here.

Abstract

Hyperbaric oxygen (HBO) therapy can attenuate neurological impairment after traumatic brain injury (TBI) and alleviate intestinal dysfunction. However, the role and mechanism of HBO therapy in intestinal dysfunction following TBI remain unclear. Herein, by establishing a mouse model of controlled cortical impact (CCI), we found that HBO therapy reduced histopathological lesions and decreased the levels of inflammatory and oedema proteins in the intestinal tissues of mice 10 days after TBI. We also showed that HBO therapy improved microbiome abundance and probiotic (particularly ) colonisation in mice post-CCI. Then, we identified that the mA level imcreased notably in injured cortical tissue of CCI+HBO group compared with the CCI group following CCI. Thus, our results suggested that HBO therapy could alleviate TBI-induced intestinal dysfunction and mA might participate in this regulation process, which provides new insights for exploring the specific mechanism and targets of HBO in the treatment of intestinal dysfunction after TBI, thereby improving the therapeutic effect of HBO.

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