Research Advances in the Function and Anti-aging Effects of Nicotinamide Mononucleotide

Overview

Journal J Zhejiang Univ Sci B

Specialties Biology
General Medicine

Date 2024 Sep 23

PMID 39308064

Authors

Min Wang

Yuan Cao

Yun Li

Lu Wang

Yuyan Liu

Zihui Deng

Lianrong Zhu

Hongjun Kang

Affiliations

Soon will be listed here.

Abstract

Aging and age-related ailments have emerged as critical challenges and great burdens within the global contemporary society. Addressing these concerns is an imperative task, with the aims of postponing the aging process and finding effective treatments for age-related degenerative diseases. Recent investigations have highlighted the significant roles of nicotinamide adenine dinucleotide (NAD) in the realm of anti-aging. It has been empirically evidenced that supplementation with nicotinamide mononucleotide (NMN) can elevate NAD levels in the body, thereby ameliorating certain age-related degenerative diseases. The principal anti-aging mechanisms of NMN essentially lie in its impact on cellular energy metabolism, inhibition of cell apoptosis, modulation of immune function, and preservation of genomic stability, which collectively contribute to the deferral of the aging process. This paper critically reviews and evaluates existing research on the anti-aging mechanisms of NMN, elucidates the inherent limitations of current research, and proposes novel avenues for anti-aging investigations.

References

Luo C, Ding W, Yang C, Zhang W, Liu X, Deng H . Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3-Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury. J Proteome Res. 2022; 21(7):1759-1770. DOI: 10.1021/acs.jproteome.2c00167. View

Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S . Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocr J. 2019; 67(2):153-160. DOI: 10.1507/endocrj.EJ19-0313. View

Zhou X, Du H, Ni L, Ran J, Hu J, Yu J . Nicotinamide Mononucleotide Combined With TKSN041 Reduces the Photoaging Damage in Murine Skin by Activating AMPK Signaling Pathway. Front Pharmacol. 2021; 12:643089. PMC: 8027253. DOI: 10.3389/fphar.2021.643089. View

Wang Q, Li Y, Dou D, Wang R, Jiang T, Wang L . Nicotinamide mononucleotide-elicited NAMPT signaling activation aggravated adjuvant-induced arthritis in rats by affecting peripheral immune cells differentiation. Int Immunopharmacol. 2021; 98:107856. DOI: 10.1016/j.intimp.2021.107856. View

Amjad S, Nisar S, Bhat A, Shah A, Frenneaux M, Fakhro K . Role of NAD in regulating cellular and metabolic signaling pathways. Mol Metab. 2021; 49:101195. PMC: 7973386. DOI: 10.1016/j.molmet.2021.101195. View

De Vos M, Schreiber V, Dantzer F . The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art. Biochem Pharmacol. 2012; 84(2):137-46. DOI: 10.1016/j.bcp.2012.03.018. View

Camacho-Pereira J, Tarrago M, Chini C, Nin V, Escande C, Warner G . CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016; 23(6):1127-1139. PMC: 4911708. DOI: 10.1016/j.cmet.2016.05.006. View

Miao Y, Cui Z, Gao Q, Rui R, Xiong B . Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes. Cell Rep. 2020; 32(5):107987. DOI: 10.1016/j.celrep.2020.107987. View

Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau D, Zavala E . NAD supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc Natl Acad Sci U S A. 2018; 115(8):E1876-E1885. PMC: 5828618. DOI: 10.1073/pnas.1718819115. View

10.

Aflatounian A, Rodriguez Paris V, Richani D, Edwards M, Cochran B, Ledger W . Declining muscle NAD in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation. Mol Metab. 2022; 65:101583. PMC: 9490589. DOI: 10.1016/j.molmet.2022.101583. View

11.

Frederick D, Loro E, Liu L, Davila Jr A, Chellappa K, Silverman I . Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab. 2016; 24(2):269-82. PMC: 4985182. DOI: 10.1016/j.cmet.2016.07.005. View

12.

Jiang Y, Liu T, Lee C, Chang Q, Yang J, Zhang Z . The NAD-mediated self-inhibition mechanism of pro-neurodegenerative SARM1. Nature. 2020; 588(7839):658-663. DOI: 10.1038/s41586-020-2862-z. View

13.

Zhao Y, Li H, Guo Q, Hui H . Multiple characteristic alterations and available therapeutic strategies of cellular senescence. J Zhejiang Univ Sci B. 2023; 24(2):101-114. PMC: 9936135. DOI: 10.1631/jzus.B2200178. View

14.

Piedra-Quintero Z, Wilson Z, Nava P, Guerau-de-Arellano M . CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity. Front Immunol. 2020; 11:597959. PMC: 7734206. DOI: 10.3389/fimmu.2020.597959. View

15.

Takeda K, Okumura K . Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice. Biomed Res. 2021; 42(5):173-179. DOI: 10.2220/biomedres.42.173. View

16.

Watroba M, Dudek I, Skoda M, Stangret A, Rzodkiewicz P, Szukiewicz D . Sirtuins, epigenetics and longevity. Ageing Res Rev. 2017; 40:11-19. DOI: 10.1016/j.arr.2017.08.001. View

17.

Brito S, Baek J, Cha B, Heo H, Lee S, Lei L . Nicotinamide mononucleotide reduces melanin production in aged melanocytes by inhibiting cAMP/Wnt signaling. J Dermatol Sci. 2022; 106(3):159-169. DOI: 10.1016/j.jdermsci.2022.05.002. View

18.

Cros C, Margier M, Cannelle H, Charmetant J, Hulo N, Laganier L . Nicotinamide Mononucleotide Administration Triggers Macrophages Reprogramming and Alleviates Inflammation During Sepsis Induced by Experimental Peritonitis. Front Mol Biosci. 2022; 9:895028. PMC: 9271973. DOI: 10.3389/fmolb.2022.895028. View

19.

Fletcher R, Ratajczak J, Doig C, Oakey L, Callingham R, Da Silva Xavier G . Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells. Mol Metab. 2017; 6(8):819-832. PMC: 5518663. DOI: 10.1016/j.molmet.2017.05.011. View

20.

Zhang G, Deng Y, Xie Q, Ren E, Ma Z, He X . Sirtuins and intervertebral disc degeneration: Roles in inflammation, oxidative stress, and mitochondrial function. Clin Chim Acta. 2020; 508:33-42. DOI: 10.1016/j.cca.2020.04.016. View