Lymphopenia in Sepsis: a Narrative Review

Overview

Journal Crit Care

Specialty Critical Care

Date 2024 Sep 20

PMID 39304908

Authors

Zhibin Wang

Wenzhao Zhang

Linlin Chen

Xin Lu

Ye Tu

Affiliations

Soon will be listed here.

Abstract

This narrative review provides an overview of the evolving significance of lymphopenia in sepsis, emphasizing its critical function in this complex and heterogeneous disease. We describe the causal relationship of lymphopenia with clinical outcomes, sustained immunosuppression, and its correlation with sepsis prediction markers and therapeutic targets. The primary mechanisms of septic lymphopenia are highlighted. In addition, the paper summarizes various attempts to treat lymphopenia and highlights the practical significance of promoting lymphocyte proliferation as the next research direction.

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