Intravenous Arachnoid Granulation Hypertrophy in Patients with Parkinson Disease

Overview

Journal NPJ Parkinsons Dis

Date 2024 Sep 20

PMID 39304673

Authors

Melanie Leguizamon

Colin D McKnight

Tristan Ponzo

Jason Elenberger

Jarrod J Eisma

Alexander K Song

Paula Trujillo

Ciaran M Considine

Manus J Donahue

Daniel O Claassen

Kilian Hett

Affiliations

Soon will be listed here.

Abstract

Intravenous arachnoid granulations (AGs) are protrusions of the arachnoid membrane into the venous lumen and function as contributors to the cerebrospinal fluid (CSF) flow circuit. Patients with Parkinson disease (PD) often present with accumulation of alpha synuclein. Previous works have provided evidence for neurofluid circulation dysfunction in neurodegenerative diseases associated with changes in CSF egress, which may have implications regarding AG morphology. The present study aims to investigate group differences in AG volumetrics between healthy and PD participants, as well as relationships between AG characteristics and clinical assessments. Generalized linear models revealed significant increases in AG volumetrics and number in PD compared to healthy controls. Partial Spearman-rank correlation analyses demonstrated significant relationships between AG metrics and motor and cognitive assessments. Finally, AG volumetrics were positively correlated with objective actigraphy measures of sleep dysfunction, but not self-report sleep symptoms.

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