Effects of Modified Video-Implemented Script Training for Aphasia in the Three Variants of Primary Progressive Aphasia

Overview

Journal J Speech Lang Hear Res

Date 2024 Sep 20

PMID 39302879

Authors

Nuria Montagut

Sergi Borrego-Ecija

Jorge Herrero

Magdalena Castellvi

Mircea Balasa

Albert Llado

Stephanie M Grasso

Raquel Sanchez-Valle

Affiliations

Soon will be listed here.

Abstract

Purpose: Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by worsening of speech and/or language. Script training intervention promotes automatized speech production via repeated practice of scripted content. This study evaluated the acceptability, feasibility, and effects of a modified version of Video-Implemented Script Training for Aphasia (VISTA) in the three PPA variants and compared outcomes by intervention modality (teletherapy vs. in person).

Method: Thirteen bilingual (Spanish-Catalan) participants were included (semantic variant, = 5; logopenic variant, = 5; nonfluent/agrammatic variant, = 3; teletherapy, = 7). Using a nonrandomized design, intervention was administered in participants' dominant language. Participants were trained on an individualized script twice per week, over 8 weeks. Performance on measures related to script accuracy, content, and subjective ratings of production quality was evaluated at baseline, immediately post, and at 3 and 6 months post-intervention.

Results: No significant differences were observed on the basis of intervention modality. Participants demonstrated significant improvements from pre- to post-intervention in script production, synonym production, keywords, and global quality on the trained script. Maintenance was observed when comparing performance at post-intervention relative to 3- and 6-month follow-up for script and synonym production. Significant improvement in production quality of the untrained topic was observed following intervention. Different patterns of benefit were observed by PPA variant.

Conclusions: Modified VISTA was acceptable and effective across the three PPA variants, as evidenced by improvements on a broader array of outcome measures than those previously reported. Findings also provide further support for provision for teletherapy in individuals with PPA.

Supplemental Material: https://doi.org/10.23641/asha.26999326.

References

Kortte K, Rogalski E . Behavioural interventions for enhancing life participation in behavioural variant frontotemporal dementia and primary progressive aphasia. Int Rev Psychiatry. 2013; 25(2):237-45. PMC: 3659798. DOI: 10.3109/09540261.2012.751017. View

Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View

Tippett D, Hillis A, Tsapkini K . Treatment of Primary Progressive Aphasia. Curr Treat Options Neurol. 2015; 17(8):362. PMC: 4600091. DOI: 10.1007/s11940-015-0362-5. View

Croot K, Ballard K, Leyton C, Hodges J . Apraxia of speech and phonological errors in the diagnosis of nonfluent/agrammatic and logopenic variants of primary progressive aphasia. J Speech Lang Hear Res. 2012; 55(5):S1562-72. DOI: 10.1044/1092-4388(2012/11-0323). View

Gorno-Tempini M, Hillis A, Weintraub S, Kertesz A, Mendez M, Cappa S . Classification of primary progressive aphasia and its variants. Neurology. 2011; 76(11):1006-14. PMC: 3059138. DOI: 10.1212/WNL.0b013e31821103e6. View

Henry M, Hubbard H, Grasso S, Mandelli M, Wilson S, Sathishkumar M . Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia. Brain. 2018; 141(6):1799-1814. PMC: 5972572. DOI: 10.1093/brain/awy101. View

Grasso S, Wagner Rodriguez C, Montagut Colomer N, Marques Kiderle S, Sanchez-Valle R, Santos Santos M . Bilingual Primary Progressive Aphasia: A Scoping Review of Assessment and Treatment Practices. J Alzheimers Dis. 2023; 96(4):1453-1476. PMC: 10900184. DOI: 10.3233/JAD-230673. View

Beales A, Cartwright J, Whitworth A, Panegyres P . Exploring generalisation processes following lexical retrieval intervention in primary progressive aphasia. Int J Speech Lang Pathol. 2016; 18(3):299-314. DOI: 10.3109/17549507.2016.1151936. View

Onken L, Carroll K, Shoham V, Cuthbert B, Riddle M . Reenvisioning Clinical Science: Unifying the Discipline to Improve the Public Health. Clin Psychol Sci. 2015; 2(1):22-34. PMC: 4374633. DOI: 10.1177/2167702613497932. View

10.

Henry M, Hubbard H, Grasso S, Dial H, Beeson P, Miller B . Treatment for Word Retrieval in Semantic and Logopenic Variants of Primary Progressive Aphasia: Immediate and Long-Term Outcomes. J Speech Lang Hear Res. 2019; 62(8):2723-2749. PMC: 6802912. DOI: 10.1044/2018_JSLHR-L-18-0144. View

11.

Grasso S, Cruz D, Benavidez R, Pena E, Henry M . Video-Implemented Script Training in a Bilingual Spanish-English Speaker With Aphasia. J Speech Lang Hear Res. 2019; 62(7):2295-2316. PMC: 6808363. DOI: 10.1044/2018_JSLHR-L-18-0048. View

12.

Cherney L, Halper A, Holland A, Cole R . Computerized script training for aphasia: preliminary results. Am J Speech Lang Pathol. 2008; 17(1):19-34. PMC: 2896889. DOI: 10.1044/1058-0360(2008/003). View

13.

Savage S, Piguet O, Hodges J . "Knowing What You Don't Know": Language Insight in Semantic Dementia. J Alzheimers Dis. 2015; 46(1):187-98. DOI: 10.3233/JAD-142703. View

14.

Wauters L, Croot K, Dial H, Duffy J, Grasso S, Kim E . Behavioral Treatment for Speech and Language in Primary Progressive Aphasia and Primary Progressive Apraxia of Speech: A Systematic Review. Neuropsychol Rev. 2023; 34(3):882-923. PMC: 11473583. DOI: 10.1007/s11065-023-09607-1. View

15.

Volkmer A, Cartwright J, Ruggero L, Beales A, Gallee J, Grasso S . Principles and philosophies for speech and language therapists working with people with primary progressive aphasia: an international expert consensus. Disabil Rehabil. 2022; 45(6):1063-1078. DOI: 10.1080/09638288.2022.2051080. View

16.

Lavoie M, Bier N, Laforce Jr R, Macoir J . Improvement in functional vocabulary and generalization to conversation following a self-administered treatment using a smart tablet in primary progressive aphasia. Neuropsychol Rehabil. 2019; 30(7):1224-1254. DOI: 10.1080/09602011.2019.1570943. View

17.

Montembeault M, Brambati S, Gorno-Tempini M, Migliaccio R . Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review. Front Neurol. 2018; 9:692. PMC: 6110931. DOI: 10.3389/fneur.2018.00692. View

18.

Dial H, Hinshelwood H, Grasso S, Hubbard H, Gorno-Tempini M, Henry M . Investigating the utility of teletherapy in individuals with primary progressive aphasia. Clin Interv Aging. 2019; 14:453-471. PMC: 6394239. DOI: 10.2147/CIA.S178878. View

19.

Gil-Navarro S, Llado A, Rami L, Castellvi M, Bosch B, Bargallo N . Neuroimaging and biochemical markers in the three variants of primary progressive aphasia. Dement Geriatr Cogn Disord. 2013; 35(1-2):106-17. DOI: 10.1159/000346289. View

20.

Harris J, Gall C, Thompson J, Richardson A, Neary D, du Plessis D . Classification and pathology of primary progressive aphasia. Neurology. 2013; 81(21):1832-9. DOI: 10.1212/01.wnl.0000436070.28137.7b. View