[Polycystic Ovary Syndrome: New and Promising Treatment Methods]

Overview

Journal Probl Endokrinol (Mosk)

Specialty Endocrinology

Date 2024 Sep 20

PMID 39302870

Authors

D M Gasieva

E V Sheremetyeva

M F Kalashnikova

F Kh Dzgoeva

E T Alborova

Affiliations

Soon will be listed here.

Abstract

Polycystic Ovary Syndrome (PCOS) - is a polygenic endocrine disorder caused by genetic, hormonal, and epigenetic factors. The importance of addressing PCOS lies in its prevalence, affecting approximately 10 to 13% of women, as well as the associated health conditions that can have a negative impact on women's lives, including infertility, dermatological manifestations of hyperandrogenism (such as hirsutism and acne), cardiovascular pathologies, metabolic disorders, and psychoemotional disorders. Currently, many theories of the development of this disease have been proposed, and as a consequence of methods of influencing and treating it. According to the clinical recommendations of the Ministry of Health of the Russian Federation, modifying the patient's lifestyle forms the basis of comprehensive therapy. We have analyzed about 60 articles on various dietary approaches to the treatment of PCOS, sourced from PubMed, Nature Reviews, Oxford Academic, Clinical Nutrition, EJOG, ScienceDirect, and MDPI. The Mediterranean diet, the DASH diet, the ketogenic diet and the low-carb diet have proven themselves the best. Also, it's necessary to add vitamin D, E, folic acid, calcium, various pro- and prebiotics to a woman's diet. Currently, the use of inositol and GPP-1 is becoming a promising method of PCOS therapy. According to the results of the analysis, a positive effect of diet therapy on the anthropometric and biochemical parameters was noted. Based on the analysis, a positive effect of diet therapy on anthropometric and biochemical parameters has been observed. It is crucial to consider the individual characteristics of each patient and not rely solely on drug therapy when approaching the treatment of PCOS.

References

Unfer V, Facchinetti F, Orru B, Giordani B, Nestler J . Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials. Endocr Connect. 2017; 6(8):647-658. PMC: 5655679. DOI: 10.1530/EC-17-0243. View

Teede H, Tay C, Laven J, Dokras A, Moran L, Piltonen T . Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2023; 108(10):2447-2469. PMC: 10505534. DOI: 10.1210/clinem/dgad463. View

Barrea L, Arnone A, Annunziata G, Muscogiuri G, Laudisio D, Salzano C . Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS). Nutrients. 2019; 11(10). PMC: 6836220. DOI: 10.3390/nu11102278. View

Lind M, Lauritzen L, Kristensen M, Ross A, Eriksen J . Effect of folate supplementation on insulin sensitivity and type 2 diabetes: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2019; 109(1):29-42. DOI: 10.1093/ajcn/nqy234. View

Kuyucu Y, Celik L, Kendirlinan O, Tap O, Mete U . Investigation of the uterine structural changes in the experimental model with polycystic ovary syndrome and effects of vitamin D treatment: An ultrastructural and immunohistochemical study. Reprod Biol. 2018; 18(1):53-59. DOI: 10.1016/j.repbio.2018.01.002. View

Wieers G, Belkhir L, Enaud R, Leclercq S, Philippart de Foy J, Dequenne I . How Probiotics Affect the Microbiota. Front Cell Infect Microbiol. 2020; 9:454. PMC: 6974441. DOI: 10.3389/fcimb.2019.00454. View

Zhang J, Sun Z, Jiang S, Bai X, Ma C, Peng Q . Probiotic V9 Regulates the Secretion of Sex Hormones in Polycystic Ovary Syndrome Patients through the Gut-Brain Axis. mSystems. 2019; 4(2). PMC: 6469956. DOI: 10.1128/mSystems.00017-19. View

Newgard C . Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metab. 2012; 15(5):606-14. PMC: 3695706. DOI: 10.1016/j.cmet.2012.01.024. View

Al-Bayyari N, Al-Domi H, Zayed F, Hailat R, Eaton A . Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial. Clin Nutr. 2020; 40(3):870-878. DOI: 10.1016/j.clnu.2020.09.024. View

10.

Lindheim L, Bashir M, Munzker J, Trummer C, Zachhuber V, Leber B . Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study. PLoS One. 2017; 12(1):e0168390. PMC: 5207627. DOI: 10.1371/journal.pone.0168390. View

11.

Sadeghi H, Adeli I, Calina D, Docea A, Mousavi T, Daniali M . Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing. Int J Mol Sci. 2022; 23(2). PMC: 8775814. DOI: 10.3390/ijms23020583. View

12.

Chen W, Pang Y . Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites. Metabolites. 2021; 11(12). PMC: 8709086. DOI: 10.3390/metabo11120869. View

13.

Ibanez L, Oberfield S, Witchel S, Auchus R, Chang R, Codner E . An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence. Horm Res Paediatr. 2017; 88(6):371-395. DOI: 10.1159/000479371. View

14.

Xiao S, Li Y, Li T, Chen M, Xu Y, Wen Y . Evidence for decreased expression of ADAMTS-1 associated with impaired oocyte quality in PCOS patients. J Clin Endocrinol Metab. 2014; 99(6):E1015-21. DOI: 10.1210/jc.2013-4177. View

15.

Szczuko M, Hawrylkowicz V, Kikut J, Drozd A . The implications of vitamin content in the plasma in reference to the parameters of carbohydrate metabolism and hormone and lipid profiles in PCOS. J Steroid Biochem Mol Biol. 2019; 198:105570. DOI: 10.1016/j.jsbmb.2019.105570. View

16.

Zeng X, Xie Y, Liu Y, Long S, Mo Z . Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity. Clin Chim Acta. 2019; 502:214-221. DOI: 10.1016/j.cca.2019.11.003. View

17.

Zhao J, Liu S, Wang Y, Wang P, Qu D, Liu M . Vitamin D improves in-vitro fertilization outcomes in infertile women with polycystic ovary syndrome and insulin resistance. Minerva Med. 2019; 110(3):199-208. DOI: 10.23736/S0026-4806.18.05946-3. View

18.

Yalle-Vasquez S, Osco-Rosales K, Nieto-Gutierrez W, Benites-Zapata V, Perez-Lopez F, Alarcon-Ruiz C . Vitamin E supplementation improves testosterone, glucose- and lipid-related metabolism in women with polycystic ovary syndrome: a meta-analysis of randomized clinical trials. Gynecol Endocrinol. 2022; 38(7):548-557. DOI: 10.1080/09513590.2022.2079629. View

19.

Kaya C, Dincer Cengiz S, Satiroglu H . Obesity and insulin resistance associated with lower plasma vitamin B12 in PCOS. Reprod Biomed Online. 2009; 19(5):721-6. DOI: 10.1016/j.rbmo.2009.06.005. View

20.

Jamilian M, Mansury S, Bahmani F, Heidar Z, Amirani E, Asemi Z . The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome. J Ovarian Res. 2018; 11(1):80. PMC: 6137747. DOI: 10.1186/s13048-018-0457-1. View