Ultrasonic-assisted Synthesis and Antitumor Evaluation of Novel Variant Heterocyclic Compounds Based on Piperidine Ring

Overview

Journal Future Med Chem

Specialties Chemistry
Pharmacy

Date 2024 Sep 20

PMID 39301894

Authors

Asmaa Aboelnaga

Eman El-Sayed Ebead

Ekhlass Nassar

Mohamed M Naguib

Mahmoud F Ismail

Affiliations

Soon will be listed here.

Abstract

This work explores the eco-friendly synthesis of various heterocycles from a piperidine-based compound () and explore their potential as antitumor agents. Ultrasonic irradiation was used to synthesize heterocycles like pyridone, thiophene and coumarin, with computational tools analyzing stability and biological interactions. Compounds and exhibit strong cytotoxic activity, surpassing doxorubicin. Compounds , , and exhibited intermediate activity, while compounds , and had minimal effects. Docking studies suggest potential ADORA1 receptor interaction. Computational tools analyze stability and interaction with biological systems, revealing potential antitumor mechanisms. Green synthesis of diverse heterocycles yielded potent antitumor agents (compounds & ). DFT and Docking studies suggest interaction with ADORA1 receptor, a potential mechanism.

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