The Mechanics of the Retina: Müller Glia Role on Retinal Extracellular Matrix and Modelling

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2024 Sep 19

PMID 39296899

Authors

Laura Prieto-Lopez

Xandra Pereiro

Elena Vecino

Affiliations

Soon will be listed here.

Abstract

The retina is a highly heterogeneous tissue, both cell-wise but also regarding its extracellular matrix (ECM). The stiffness of the ECM is pivotal in retinal development and maturation and has also been associated with the onset and/or progression of numerous retinal pathologies, such as glaucoma, proliferative vitreoretinopathy (PVR), age-related macular degeneration (AMD), epiretinal membrane (ERM) formation or uveitis. Nonetheless, much remains unknown about the biomechanical milieu of the retina, and specifically the role that Müller glia play as principal mechanosensors and major producers of ECM constituents. So far, new approaches need to be developed to further the knowledge in the field of retinal mechanobiology for ECM-target applications to arise. In this review, we focus on the involvement of Müller glia in shaping and altering the retinal ECM under both physiological and pathological conditions and look into various biomaterial options to more accurately replicate the impact of matrix stiffness

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References

Galie P, Westfall M, Stegemann J . Reduced serum content and increased matrix stiffness promote the cardiac myofibroblast transition in 3D collagen matrices. Cardiovasc Pathol. 2011; 20(6):325-33. PMC: 3110608. DOI: 10.1016/j.carpath.2010.10.001. View

Wiemann S, Yousf A, Joachim S, Peters C, Mueller-Buehl A, Wagner N . Knock-Out of Tenascin-C Ameliorates Ischemia-Induced Rod-Photoreceptor Degeneration and Retinal Dysfunction. Front Neurosci. 2021; 15:642176. PMC: 8172977. DOI: 10.3389/fnins.2021.642176. View

Howard J, Bechstedt S . Hypothesis: a helix of ankyrin repeats of the NOMPC-TRP ion channel is the gating spring of mechanoreceptors. Curr Biol. 2004; 14(6):R224-6. DOI: 10.1016/j.cub.2004.02.050. View

Lee M, Rodansky E, Smith J, Rodgers G . ADAMTS13 promotes angiogenesis and modulates VEGF-induced angiogenesis. Microvasc Res. 2012; 84(2):109-15. DOI: 10.1016/j.mvr.2012.05.004. View

Doyle A, Yamada K . Mechanosensing via cell-matrix adhesions in 3D microenvironments. Exp Cell Res. 2015; 343(1):60-66. PMC: 4851608. DOI: 10.1016/j.yexcr.2015.10.033. View

De Groef L, Andries L, Lemmens K, Van Hove I, Moons L . Matrix metalloproteinases in the mouse retina: a comparative study of expression patterns and MMP antibodies. BMC Ophthalmol. 2015; 15:187. PMC: 4696081. DOI: 10.1186/s12886-015-0176-y. View

Vasan S, Foiles P, Founds H . Therapeutic potential of breakers of advanced glycation end product-protein crosslinks. Arch Biochem Biophys. 2003; 419(1):89-96. DOI: 10.1016/j.abb.2003.08.016. View

Poitelon Y, Lopez-Anido C, Catignas K, Berti C, Palmisano M, Williamson C . YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells. Nat Neurosci. 2016; 19(7):879-87. PMC: 4925303. DOI: 10.1038/nn.4316. View

Ilochonwu B, Mihajlovic M, Maas-Bakker R, Rousou C, Tang M, Chen M . Hyaluronic Acid-PEG-Based Diels-Alder Forming Hydrogels for Sustained Intraocular Delivery of Bevacizumab. Biomacromolecules. 2022; 23(7):2914-2929. PMC: 9277588. DOI: 10.1021/acs.biomac.2c00383. View

10.

Nagai N, Klimava A, Lee W, Izumi-Nagai K, Handa J . CTGF is increased in basal deposits and regulates matrix production through the ERK (p42/p44mapk) MAPK and the p38 MAPK signaling pathways. Invest Ophthalmol Vis Sci. 2008; 50(4):1903-10. PMC: 2729056. DOI: 10.1167/iovs.08-2383. View

11.

Soofi S, Last J, Liliensiek S, Nealey P, Murphy C . The elastic modulus of Matrigel as determined by atomic force microscopy. J Struct Biol. 2009; 167(3):216-9. PMC: 2747304. DOI: 10.1016/j.jsb.2009.05.005. View

12.

Garcia M, Forster V, Hicks D, Vecino E . Effects of müller glia on cell survival and neuritogenesis in adult porcine retina in vitro. Invest Ophthalmol Vis Sci. 2002; 43(12):3735-43. View

13.

Hernandez H, Medina-Ortiz W, Luan T, Clark A, McDowell C . Crosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular Meshwork. Invest Ophthalmol Vis Sci. 2017; 58(3):1811-1823. PMC: 5374883. DOI: 10.1167/iovs.16-21331. View

14.

Taylor L, Arner K, Engelsberg K, Ghosh F . Scaffolding the retina: the interstitial extracellular matrix during rat retinal development. Int J Dev Neurosci. 2015; 42:46-58. DOI: 10.1016/j.ijdevneu.2015.03.002. View

15.

Li X, Sun Q, Li Q, Kawazoe N, Chen G . Functional Hydrogels With Tunable Structures and Properties for Tissue Engineering Applications. Front Chem. 2018; 6:499. PMC: 6204355. DOI: 10.3389/fchem.2018.00499. View

16.

Cui J, Chiu A, Maberley D, Ma P, Samad A, Matsubara J . Stage specificity of novel growth factor expression during development of proliferative vitreoretinopathy. Eye (Lond). 2006; 21(2):200-8. DOI: 10.1038/sj.eye.6702169. View

17.

Bu S, Kuijer R, Van der Worp R, Huiskamp E, Renardel de Lavalette V, Li X . Glial cells and collagens in epiretinal membranes associated with idiopathic macular holes. Retina. 2013; 34(5):897-906. DOI: 10.1097/IAE.0000000000000013. View

18.

George A, Homme R, Majumder A, Tyagi S, Singh M . Effect of gene knockout on retinal vascular form and function. Physiol Genomics. 2019; 51(12):613-622. PMC: 6962592. DOI: 10.1152/physiolgenomics.00041.2019. View

19.

Koch T, Munster S, Bonakdar N, Butler J, Fabry B . 3D Traction forces in cancer cell invasion. PLoS One. 2012; 7(3):e33476. PMC: 3316584. DOI: 10.1371/journal.pone.0033476. View

20.

Ruzafa N, Vecino E . Effect of Müller cells on the survival and neuritogenesis in retinal ganglion cells. Arch Soc Esp Oftalmol. 2015; 90(11):522-6. DOI: 10.1016/j.oftal.2015.03.009. View