Cyclodextrin-Based Nanogels for Stabilization and Sensing of Curcumin

Overview

Journal ACS Appl Nano Mater

Publisher American Chemical Society

Date 2024 Sep 19

PMID 39296865

Authors

Maria Antonietta Casulli

Ruyu Yan

Satomi Takeuchi

Andrea Cesari

Fabrizio Mancin

Takashi Hayashita

Takeshi Hashimoto

Irene Taurino

Affiliations

Soon will be listed here.

Abstract

Curcumin (CUR), a polyphenolic substance from turmeric, displays diverse medicinal properties. However, its instability poses challenges in detection. Cyclodextrin-based nanogels (CyDngs) offer a transformative solution, enhancing CUR's stability in aqueous solutions. Multisensing approaches involving fluorescence, electrochemistry, and NMR spectroscopy were employed, demonstrating CyDngs' pivotal role in CUR detection. Langmuir analysis revealed a binding constant of 1.4 × 10 M for CyDngs, highlighting their effectiveness over native β-CyDs. The study emphasized CyDngs' superiority in stabilizing CUR and enabling reliable and sensitive detection with very diverse methods.

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