Neurological Outcomes and Associated Perinatal Factors in Infants Born Between 22 and 25 Weeks with Active Care

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2024 Sep 18

PMID 39294298

Authors

Yu Ariyoshi

Takayuki Iriyama

Takahiro Seyama

Seisuke Sayama

Eriko Yano

Kensuke Suzuki

Taiki Samejima

Mari Ichinose

Masatake Toshimitsu

Kenbun Sone

Atsushi Ito

Yoshihiko Shitara

Keiichi Kumasawa

Kohei Kashima

Satsuki Kakiuchi

Yasushi Hirota

Naoto Takahashi

Yutaka Osuga

Affiliations

Soon will be listed here.

Abstract

Objectives: To elucidate the outcomes of periviable infants receiving active care (AC) and explore perinatal factors associated with neurodevelopmental outcomes.

Methods: This is a single-center retrospective study on infants born at 22-25 weeks of gestation, all of whom received AC. A developmental quotient (DQ) ≥ 85 at corrected 18 months was judged as normal.

Results: Fifty-seven infants were included in the study. The survival rates at discharge were 83%, 86%, 93%, and 93% at 22, 23, 24, and 25 gestational weeks, respectively. The overall percentage of normal DQ was 26/47 (55%). Acidemia in the arterial blood gas measured within 6 h after birth was identified as a factor significantly associated with subnormal DQ.

Conclusions: Not only high survival rates, but also favorable neurodevelopmental outcomes may be achieved by AC in periviable infants. Moreover, impaired neurodevelopmental outcomes may be associated with early postnatal acidemia following initial resuscitation.

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