Research Progress on Ferroptosis in Multiple Myeloma

Overview

Journal Curr Treat Options Oncol

Specialty Oncology

Date 2024 Sep 17

PMID 39287715

Authors

Po Li

Tianxin Lyu

Affiliations

Soon will be listed here.

Abstract

Multiple myeloma (MM) is the second most common hematological malignant (HM) tumor, and a large proportion of patients still suffer from treatment failure and a poor prognosis despite the use of some newly approved drugs, a deeper understanding of the underlying mechanism is still needed. Ferroptosis is a new form of programmed cell death (PCD) that is different from other traditional forms of cell death such as apoptosis, necrosis and autophagy. With the continuous deepening of research on ferroptosis, ferroptosis has been found to be closely related to MM. This article reviews the regulatory mechanism of ferroptosis and research progress on ferroptosis in MM, providing a new theoretical basis and strategies for the diagnosis and treatment of MM.

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