Histamine H1 Receptor Participation in the Control of Prolactin Secretion in Postpartum

Overview

Journal J Endocrinol Invest

Publisher Springer

Specialty Endocrinology

Date 1985 Apr 1

PMID 3928731

Citations 2

Authors

I E Messinis

A Souvatzoglou

N Fais

D Lolis

Affiliations

Soon will be listed here.

Abstract

It has been reported that cimetidine, an H2-receptor antagonist, stimulates PRL secretion in postpartum. In the present study, the PRL response to two H1-receptor antagonists, promethazine and d-chlorpheniramine, was studied in 38 normal puerperal women on day 1 after delivery. Serum PRL levels decreased significantly after a single dose of promethazine (100 mg) given im (5 women) or d-chlorpheniramine (20 mg) given iv (6 women). In contrast, no significant change in PRL levels was observed after only saline infusion (6 women). Promethazine, given concomitantly to an iv bolus injection of TRH (200 micrograms) (6 women) and d-chlorpheniramine, given at the onset of suckling (6 women), did not alter stimulation of PRL release induced by these challenges. These results suggest the involvement of histamine H1 receptors in the regulation of basal PRL secretion in postpartum and would indicate that they do not participate in the mechanisms underlying suckling-induced PRL release.

Citing Articles

Drugs in Lactation.

Anderson P Pharm Res. 2018; 35(3):45.

PMID: 29411152 DOI: 10.1007/s11095-017-2287-z.

Effect of cimetidine on maternal and fetal prolactin secretion during labor.

Messinis I, Tsirkas N, Diamantis K, Vasakos S, Tsolas O, Lolis D J Endocrinol Invest. 1988; 11(11):785-8.

PMID: 3225400 DOI: 10.1007/BF03350225.

References

Pontiroli A, De Castro E Silva E, Mazzoleni F, Alberetto M, Baio G, Pellicciotta G . The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981; 52(5):924-8. DOI: 10.1210/jcem-52-5-924. View

Szabo M, Frohman L . Central nervous system-mediated stimulation of prolactin secretion by cimetidine, a histamine H2-receptor antagonist: impaired responsiveness in patients with prolactin-secreting tumors and idiopathic hyperprolactinemia. J Clin Endocrinol Metab. 1980; 51(6):1417-24. DOI: 10.1210/jcem-51-6-1417. View

Messinis I, Souvatzoglou A, Fais N, Lolis D . Effect of cimetidine on prolactin secretion in postpartum women. Horm Metab Res. 1983; 15(7):360. DOI: 10.1055/s-2007-1018722. View

Sharpe P, Melvin M, Mills J, Burland W, Groom G . Prolactin responses to histamine H2 receptor antagonists. Acta Endocrinol (Copenh). 1980; 95(3):308-13. DOI: 10.1530/acta.0.0950308. View

Messinis I, Lolis D, Kanellopoulos N, Dalkalitsis N, Kanaris C . TRH injection during labour: effect on maternal and fetal prolactin secretion. Clin Endocrinol (Oxf). 1982; 16(2):193-8. DOI: 10.1111/j.1365-2265.1982.tb03164.x. View

Delitala G, Stubbs W, Wass J, Jones A, Williams S, Besser G . Effects of the H2 receptor antagonist cimetidine on pituitary hormones in man. Clin Endocrinol (Oxf). 1979; 11(2):161-7. DOI: 10.1111/j.1365-2265.1979.tb03061.x. View

Chapler F, Sherman B, Swanson J . The effects of an antihistamine and/or a glucocorticoid on the prolactin response to surgical procedures. Am J Obstet Gynecol. 1978; 132(4):367-72. DOI: 10.1016/0002-9378(78)90769-x. View

Carlson H, Ippoliti A . Cimetidine, an H2-antihistamine, stimulates prolactin secretion in man. J Clin Endocrinol Metab. 1977; 45(2):367-70. DOI: 10.1210/jcem-45-2-367. View

Knigge U, Dejgaard A, Wollesen F, Thuesen B, Christiansen P . Histamine regulation of prolactin secretion through H1- and H2-receptors. J Clin Endocrinol Metab. 1982; 55(1):118-22. DOI: 10.1210/jcem-55-1-118. View

10.

Arakelian M, Libertun C . H1 and H2 histamine receptor participation in the brain control of prolactin secretion in lactating rats. Endocrinology. 1977; 100(3):890-5. DOI: 10.1210/endo-100-3-890. View

11.

Iodice M, Lombardi G, TOMMASELLI A, Rossi R, Annunziato L, Minozzi M . Agreement of prolactin response to cimetidine and nomifensine in patients with prolactin-secreting tumors and idiopathic hyperprolactinemia. Neuroendocrinology. 1982; 35(5):333-5. DOI: 10.1159/000123403. View

12.

Clemens J, Smalstig E, Sawyer B . Antipsychotic drugs stimulate prolactin release. Psychopharmacologia. 1974; 40(2):123-7. DOI: 10.1007/BF00421361. View

13.

Tyson J, Hwang P, Guyda H, Friesen H . Studies of prolactin secretion in human pregnancy. Am J Obstet Gynecol. 1972; 113(1):14-20. DOI: 10.1016/0002-9378(72)90446-2. View