Phytochemical, Biological, and Nutritional Properties of the Prickly Pear, : A Review

Overview

Journal Saudi Pharm J

Specialty Pharmacy

Date 2024 Sep 17

PMID 39286769

Authors

El Hassania Loukili

Mohammed Merzouki

Mohamed Taibi

Amine Elbouzidi

Belkheir Hammouti

Krishna Kumar Yadav

Mohammad Khalid

Mohamed Addi

Mohammed Ramdani

Pankaj Kumar

Jeong Ryeol Choi

Affiliations

Soon will be listed here.

Abstract

Opuntia (Cactaceae) species are native to arid and semi-arid regions of Mexico and the southern United States and grow in various climatic zones. is a cactus fruit with many beneficial properties, and it is used as a medicinal plant in various countries. This review paper provides updated information on the phytochemical and pharmacological aspects of . The fruit contains valuable compounds such as flavonoids, phenolics, ascorbic acid, betanin, and essential elements, which have been isolated and identified. The fruit also exhibits diverse pharmacological activities, such as antioxidant, anti-inflammatory, anti-tumor, neuroprotective, hepatoprotective, hypotensive, anti-diabetic, antifungal, and anticancer effects. Moreover, molecular docking and ADMET predictions were performed to evaluate the antibacterial potential of the fruit against protein. This paper suggests that has significant potential as a complementary therapy for various pathological conditions.

References

Galati E, Mondello M, Lauriano E, Taviano M, Galluzzo M, Miceli N . Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury. Phytother Res. 2005; 19(9):796-800. DOI: 10.1002/ptr.1741. View

Giraldo-Silva L, Ferreira B, Rosa E, Dias A . Fruit: A Systematic Review of Its Phytochemicals and Pharmacological Activities. Plants (Basel). 2023; 12(3). PMC: 9919935. DOI: 10.3390/plants12030543. View

Rajagopal K, Varakumar P, Baliwada A, Byran G . Activity of phytochemical constituents of (turmeric) and against coronavirus (COVID-19): an in silico approach. Futur J Pharm Sci. 2020; 6(1):104. PMC: 7562761. DOI: 10.1186/s43094-020-00126-x. View

Berraaouan A, Abderrahim Z, Hassane M, Abdelkhaleq L, Mohammed A, Mohamed B . Evaluation of protective effect of cactus pear seed oil (Opuntia ficus-indica L. MILL.) against alloxan-induced diabetes in mice. Asian Pac J Trop Med. 2015; 8(7):532-7. DOI: 10.1016/j.apjtm.2015.06.013. View

Jiang J, Li Y, Chen Z, Min Z, Lou F . Two novel C29-5beta-sterols from the stems of Opuntia dillenii. Steroids. 2006; 71(13-14):1073-7. DOI: 10.1016/j.steroids.2006.09.005. View

Qiu Y, Chen Y, Pei Y, Matsuda H, Yoshikawa M . Constituents with radical scavenging effect from Opuntia dillenii: structures of new alpha-pyrones and flavonol glycoside. Chem Pharm Bull (Tokyo). 2002; 50(11):1507-10. DOI: 10.1248/cpb.50.1507. View

Qiu Y, Dou D, Pei Y, Yoshikawa M, Matsuda H, Chen Y . [The isolation and identification of a new alpha-pyrone from Opuntia dillenii]. Yao Xue Xue Bao. 2003; 38(7):523-5. View

Bouhrim M, Daoudi N, Ouassou H, Benoutman A, Loukili E, Ziyyat A . Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Seed Oil. ScientificWorldJournal. 2020; 2020:5717052. PMC: 7557898. DOI: 10.1155/2020/5717052. View

Brahmi D, Bouaziz C, Ayed Y, Ben Mansour H, Zourgui L, Bacha H . Chemopreventive effect of cactus Opuntia ficus indica on oxidative stress and genotoxicity of aflatoxin B1. Nutr Metab (Lond). 2011; 8:73. PMC: 3214131. DOI: 10.1186/1743-7075-8-73. View

10.

Hensley K, Benaksas E, Bolli R, Comp P, Grammas P, Hamdheydari L . New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine. Free Radic Biol Med. 2004; 36(1):1-15. DOI: 10.1016/j.freeradbiomed.2003.10.009. View

11.

Park E, Kahng J, Lee S, Shin K . An anti-inflammatory principle from cactus. Fitoterapia. 2001; 72(3):288-90. DOI: 10.1016/s0367-326x(00)00287-2. View

12.

Khan M, Giridhar P . Plant betalains: Chemistry and biochemistry. Phytochemistry. 2015; 117:267-295. DOI: 10.1016/j.phytochem.2015.06.008. View

13.

Cejudo-Bastante M, Chaalal M, Louaileche H, Parrado J, Heredia F . Betalain profile, phenolic content, and color characterization of different parts and varieties of Opuntia ficus-indica. J Agric Food Chem. 2014; 62(33):8491-9. DOI: 10.1021/jf502465g. View

14.

Cheeseman K, Slater T . An introduction to free radical biochemistry. Br Med Bull. 1993; 49(3):481-93. DOI: 10.1093/oxfordjournals.bmb.a072625. View

15.

Elbouzidi A, Taibi M, Laaraj S, Loukili E, Haddou M, El Hachlafi N . Chemical profiling of volatile compounds of the essential oil of grey-leaved rockrose ( L.) and its antioxidant, anti-inflammatory, antibacterial, antifungal, and anticancer activity and . Front Chem. 2024; 12:1334028. PMC: 10905769. DOI: 10.3389/fchem.2024.1334028. View

16.

Loukili E, Ouahabi S, Elbouzidi A, Taibi M, Yahyaoui M, Asehraou A . Phytochemical Composition and Pharmacological Activities of Three Essential Oils Collected from Eastern Morocco , , and : A Comparative Study. Plants (Basel). 2023; 12(19). PMC: 10574104. DOI: 10.3390/plants12193376. View

17.

Rice-Evans C, Miller N, Paganga G . Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med. 1996; 20(7):933-56. DOI: 10.1016/0891-5849(95)02227-9. View

18.

Sendker J, Lechtenberg M, Hensel A . An Unsuccessful Attempt to Confirm the Occurrence of 4'-O-β- d-Glucosyl-9-O-(6″-deoxysaccharosyl)olivil in Valerian Root. Planta Med. 2020; 86(15):1133-1139. DOI: 10.1055/a-1078-5195. View

19.

Smeriglio A, De Francesco C, Denaro M, Trombetta D . Prickly Pear Betalain-Rich Extracts as New Promising Strategy for Intestinal Inflammation: Plant Complex vs. Main Isolated Bioactive Compounds. Front Pharmacol. 2021; 12:722398. PMC: 8476807. DOI: 10.3389/fphar.2021.722398. View

20.

Smeriglio A, Bonasera S, Germano M, DAngelo V, Barreca D, Denaro M . Opuntia ficus-indica (L.) Mill. fruit as source of betalains with antioxidant, cytoprotective, and anti-angiogenic properties. Phytother Res. 2019; 33(5):1526-1537. DOI: 10.1002/ptr.6345. View