Suzuki-Miyaura Cross-coupling of Unprotected -bromoanilines with Benzyl, Alkyl, Aryl, Alkenyl and Heteroaromatic Boronic Esters

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2024 Sep 17

PMID 39285872

Authors

Alexandra E Lubaev

Christopher C Marvin

Amanda W Dombrowski

Zafar Qureshi

Affiliations

Soon will be listed here.

Abstract

A Suzuki-Miyaura cross-coupling reaction was developed on unprotected -bromoanilines. This operationally simple reaction was developed for the diversification of glucocorticoid receptor modulators (GRMs), showed compatibility to various boronic esters featuring unique functionalities, and was demonstrated on a gram scale.

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