Article: Carbonic anhydrase in the carotid body and the carotid sinus nerve

It is well known that carbonic anhydrase plays an important role in the physiological responses of carotid-body chemoreceptors to hypercapnia. Nevertheless the precise location of the enzyme within the carotid body has been a matter of controversy for many years. Using the Hansson method we found histochemical evidence that this enzyme is localized in type I cells. Type II cells and nerve terminals did not show enzymatic activity. These results allow us to define the carotid body as a secondary receptor in the context of the "acidic hypothesis" of transduction in the carotid body.

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Carbonic Anhydrase in the Carotid Body and the Carotid Sinus Nerve