Bidirectional Mendelian Randomization Highlights Causal Relationships Between Circulating INHBC and Multiple Cardiometabolic Diseases and Traits

Overview

Journal Diabetes

Specialty Endocrinology

Date 2024 Sep 16

PMID 39283655

Authors

Nellie Y Loh

Daniel B Rosoff

Rebecca Richmond

Raymond Noordam

George Davey Smith

David Ray

Fredrik Karpe

Falk W Lohoff

Constantinos Christodoulides

Affiliations

Soon will be listed here.

Abstract

Article Highlights:

References

Tsuchida K, Nakatani M, Yamakawa N, Hashimoto O, Hasegawa Y, Sugino H . Activin isoforms signal through type I receptor serine/threonine kinase ALK7. Mol Cell Endocrinol. 2004; 220(1-2):59-65. DOI: 10.1016/j.mce.2004.03.009. View

Schmidt A, Finan C, Gordillo-Maranon M, Asselbergs F, Freitag D, Patel R . Genetic drug target validation using Mendelian randomisation. Nat Commun. 2020; 11(1):3255. PMC: 7320010. DOI: 10.1038/s41467-020-16969-0. View

Hemani G, Zheng J, Elsworth B, Wade K, Haberland V, Baird D . The MR-Base platform supports systematic causal inference across the human phenome. Elife. 2018; 7. PMC: 5976434. DOI: 10.7554/eLife.34408. View

Giambartolomei C, Vukcevic D, Schadt E, Franke L, Hingorani A, Wallace C . Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet. 2014; 10(5):e1004383. PMC: 4022491. DOI: 10.1371/journal.pgen.1004383. View

Koprulu M, Zhao Y, Wheeler E, Dong L, Rocha N, Li C . Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution. J Clin Endocrinol Metab. 2021; 107(4):1065-1077. PMC: 8947777. DOI: 10.1210/clinem/dgab877. View

Gudmundsdottir V, Zaghlool S, Emilsson V, Aspelund T, Ilkov M, Gudmundsson E . Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes. Diabetes. 2020; 69(8):1843-1853. PMC: 7372075. DOI: 10.2337/db19-1070. View

Weissbrod O, Hormozdiari F, Benner C, Cui R, Ulirsch J, Gazal S . Functionally informed fine-mapping and polygenic localization of complex trait heritability. Nat Genet. 2020; 52(12):1355-1363. PMC: 7710571. DOI: 10.1038/s41588-020-00735-5. View

Ibanez C . Regulation of metabolic homeostasis by the TGF-β superfamily receptor ALK7. FEBS J. 2021; 289(19):5776-5797. DOI: 10.1111/febs.16090. View

Cronje H, Mi M, Austin T, Biggs M, Siscovick D, Lemaitre R . Plasma Proteomic Risk Markers of Incident Type 2 Diabetes Reflect Physiologically Distinct Components of Glucose-Insulin Homeostasis. Diabetes. 2023; 72(5):666-673. PMC: 10130486. DOI: 10.2337/db22-0628. View

10.

Adam R, Pryce D, Lee J, Zhao Y, Mintah I, Min S . Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice. Proc Natl Acad Sci U S A. 2023; 120(32):e2309967120. PMC: 10410708. DOI: 10.1073/pnas.2309967120. View

11.

Tissink E, Werme J, de Lange S, Savage J, Wei Y, de Leeuw C . The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks. eNeuro. 2023; 10(4). PMC: 10089056. DOI: 10.1523/ENEURO.0242-22.2023. View

12.

Goebel E, Ongaro L, Kappes E, Vestal K, Belcheva E, Castonguay R . The orphan ligand, activin C, signals through activin receptor-like kinase 7. Elife. 2022; 11. PMC: 9224996. DOI: 10.7554/eLife.78197. View

13.

Strom K, Gundersen T, Hansson O, Lucas S, Fernandez C, Blomhoff R . Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL. FASEB J. 2009; 23(7):2307-16. DOI: 10.1096/fj.08-120923. View

14.

Ferkingstad E, Sulem P, Atlason B, Sveinbjornsson G, Magnusson M, Styrmisdottir E . Large-scale integration of the plasma proteome with genetics and disease. Nat Genet. 2021; 53(12):1712-1721. DOI: 10.1038/s41588-021-00978-w. View

15.

Sun B, Chiou J, Traylor M, Benner C, Hsu Y, Richardson T . Plasma proteomic associations with genetics and health in the UK Biobank. Nature. 2023; 622(7982):329-338. PMC: 10567551. DOI: 10.1038/s41586-023-06592-6. View

16.

Cohen J, Boerwinkle E, Mosley Jr T, Hobbs H . Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med. 2006; 354(12):1264-72. DOI: 10.1056/NEJMoa054013. View

17.

Schreiber R, Hofer P, Taschler U, Voshol P, Rechberger G, Kotzbeck P . Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proc Natl Acad Sci U S A. 2015; 112(45):13850-5. PMC: 4653216. DOI: 10.1073/pnas.1516004112. View

18.

Abifadel M, Varret M, Rabes J, Allard D, Ouguerram K, Devillers M . Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet. 2003; 34(2):154-6. DOI: 10.1038/ng1161. View

19.

Ray K, Troquay R, Visseren F, Leiter L, Wright R, Vikarunnessa S . Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): results from the 4-year open-label extension of the ORION-1 trial. Lancet Diabetes Endocrinol. 2023; 11(2):109-119. DOI: 10.1016/S2213-8587(22)00353-9. View

20.

Sanderson E, Davey Smith G, Windmeijer F, Bowden J . An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings. Int J Epidemiol. 2018; 48(3):713-727. PMC: 6734942. DOI: 10.1093/ije/dyy262. View