Effects of Maternal Nonylphenol Exposure on the Proliferation of Glial Cells in the Brain of Male Offspring Mice

Overview

Journal Anim Cells Syst (Seoul)

Specialty Biology

Date 2024 Sep 16

PMID 39280932

Authors

Seung Hyun Lee

Hyun Seung Shin

Yun Hee So

Dong Hun Lee

Jin Yeop Kim

Eun-Hee Lee

Eui-Man Jung

Affiliations

Soon will be listed here.

Abstract

Glial cells play a significant role in maintaining brain homeostasis and normal brain development, and their functions can be impaired by exposure to endocrine disruptors. 4-n-Nonylphenol (NP), a representative endocrine disruptor, is widely used in personal care products and industrial materials. NP accumulates in various organs, including the brain, of living organisms and adversely influences brain health. However, studies on the effects of NP on glial cells are limited. This study aims to investigate the effects of NP on glial cells using primary mixed glial cells and offspring mice exposed to NP during gestation and lactation. experiments revealed that NP exposure stimulated the astrocytes and microglia proliferation but not oligodendrocytes. NP exposure activated microglia and reduced myelin protein expression in oligodendrocytes. Moreover, maternal NP exposure increased the numbers of microglia and oligodendrocytes in the cerebral cortex of adult offspring. NP exposure caused anxiety- and depressive-like behaviors in adult mice. Collectively, these findings suggest that maternal NP exposure negatively affects the brain development in adult offspring mice.

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