Bioactive Molecules Delivery Through Ferritin Nanoparticles: Sum Up of Current Loading Methods

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Sep 14

PMID 39274893

Authors

Rosanna Lucignano

Giarita Ferraro

Affiliations

Soon will be listed here.

Abstract

Ferritin (Ft) is a protein with a peculiar three-dimensional architecture. It is characterized by a hollow cage structure and is responsible for iron storage and detoxification in almost all living organisms. It has attracted the interest of the scientific community thanks to its appealing features, such as its nano size, thermal and pH stability, ease of functionalization, and low cost for large-scale production. Together with high storage capacity, these properties qualify Ft as a promising nanocarrier for the development of delivery systems for numerous types of biologically active molecules. In this paper, we introduce the basic structural and functional aspects of the protein, and summarize the methods employed to load bioactive molecules within the ferritin nanocage.

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