Development and Prospects of Furin Inhibitors for Therapeutic Applications

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Sep 14

PMID 39273149

Authors

Alexandre V Ivachtchenko

Alexander V Khvat

Dmitrii O Shkil

Affiliations

Soon will be listed here.

Abstract

Furin, a serine protease enzyme located in the Golgi apparatus of animal cells, plays a crucial role in cleaving precursor proteins into their mature, active forms. It is ubiquitously expressed across various tissues, including the brain, lungs, gastrointestinal tract, liver, pancreas, and reproductive organs. Since its discovery in 1990, furin has been recognized as a significant therapeutic target, leading to the active development of furin inhibitors for potential use in antiviral, antibacterial, anticancer, and other therapeutic applications. This review provides a comprehensive overview of the progress in the development and characterization of furin inhibitors, encompassing peptides, linear and macrocyclic peptidomimetics, and non-peptide compounds, highlighting their potential in the treatment of both infectious and non-infectious diseases.

Citing Articles

Identification of Furin Protease Small-Molecule Inhibitor with a 1,3-Thiazol-2-ylaminosulfonyl Scaffold.

Kolaric A, Ravnik V, Stumpf Horvat S, Jukic M, Bren U Pharmaceuticals (Basel). 2025; 18(2).

PMID: 40006084 PMC: 11859198. DOI: 10.3390/ph18020273.

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