Observational Study of Men and Women with Breast Cancer in Terms of Overall Survival

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2024 Sep 14

PMID 39272907

Authors

Vlad Bogdan Varzaru

Diana-Maria Anastasiu-Popov

Anca-Elena Eftenoiu

Roxana Popescu

Daliborca Cristina Vlad

Cristian Sebastian Vlad

Aurica Elisabeta Moatar

Daniela Puscasiu

Ionut Marcel Cobec

Affiliations

Soon will be listed here.

Abstract

Material And Method: This cohort study represents a retrospective and anonymized data analysis of 2162 breast cancer cases (19 males and 2143 females), registered over a period of 12 years, from 1 January 2010 to 31 December 2021, in the Clinic of Obstetrics and Gynecology, Diakoneo Diak Klinikum Schwäbisch Hall, Germany.

Results: According to the Kaplan-Meier survival analysis, the estimated overall 3-year survival rate was 91.1% for women and 88.9% for men. The log-rank test of equality of survival distributions indicated a statistically significant difference in survival times between the two groups ( = 0.009). In the subsequent age-matched Kaplan-Meier analysis, the -value was below the significance threshold ( = 0.068).

Conclusions: Male breast cancer is a rare disease that may show some particularities in terms of survival compared to female breast cancer.

Citing Articles

Efficacy and Safety of Paclitaxel-Based PD-1/PD-L1 Immunotherapies for Triple-Negative Breast Cancer: A Systematic Review and Network Meta-Analysis.

Dai Y, Ruan T, Yang W, Liu S, Chen J, Fang Y Clin Med Insights Oncol. 2024; 18:11795549241308072.

PMID: 39734512 PMC: 11672372. DOI: 10.1177/11795549241308072.

Comprehensive Analysis of Receptor Status, Histopathological Classifications (B1-B5), and Cumulative Histological Dimensions in Breast Cancer: Predictors of Malignancy and Diagnostic Implications.

Burciu O, Sas I, Merce A, Cerbu S, Moatar A, Eftenoiu A Cancers (Basel). 2024; 16(20).

PMID: 39456566 PMC: 11506213. DOI: 10.3390/cancers16203471.

References

Hennequin C, Belkacemi Y, Bourgier C, Cowen D, Cutuli B, Fourquet A . Radiotherapy of breast cancer. Cancer Radiother. 2021; 26(1-2):221-230. DOI: 10.1016/j.canrad.2021.11.013. View

Lin A, Huang T, Tam K . Treatment of male breast cancer: meta-analysis of real-world evidence. Br J Surg. 2021; 108(9):1034-1042. DOI: 10.1093/bjs/znab279. View

Silvestri V, Valentini V, Bucalo A, Conti G, Manzella L, Turchetti D . HER2-Low Expression in Male Breast Cancer: Results from a Multicenter Series in Italy. Cancers (Basel). 2024; 16(3). PMC: 10854762. DOI: 10.3390/cancers16030548. View

Caetano Dos Santos F, Michalek I, Wojciechowska U, Didkowska J . Changes in the survival of patients with breast cancer: Poland, 2000-2019. Breast Cancer Res Treat. 2022; 197(3):623-631. PMC: 9744367. DOI: 10.1007/s10549-022-06828-5. View

Pal T, Agnese D, Daly M, La Spada A, Litton J, Wick M . Points to consider: is there evidence to support BRCA1/2 and other inherited breast cancer genetic testing for all breast cancer patients? A statement of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2019; 22(4):681-685. DOI: 10.1038/s41436-019-0712-x. View

Stalsberg H, Thomas D, Rosenblatt K, Jimenez L, McTiernan A, Stemhagen A . Histologic types and hormone receptors in breast cancer in men: a population-based study in 282 United States men. Cancer Causes Control. 1993; 4(2):143-51. DOI: 10.1007/BF00053155. View

Greif J, Pezzi C, Klimberg V, Bailey L, Zuraek M . Gender differences in breast cancer: analysis of 13,000 breast cancers in men from the National Cancer Data Base. Ann Surg Oncol. 2012; 19(10):3199-204. DOI: 10.1245/s10434-012-2479-z. View

Wang F, Shu X, Meszoely I, Pal T, Mayer I, Yu Z . Overall Mortality After Diagnosis of Breast Cancer in Men vs Women. JAMA Oncol. 2019; 5(11):1589-1596. PMC: 6753503. DOI: 10.1001/jamaoncol.2019.2803. View

Grinda T, Antoine A, Jacot W, Blaye C, Cottu P, Dieras V . Evolution of overall survival and receipt of new therapies by subtype among 20 446 metastatic breast cancer patients in the 2008-2017 ESME cohort. ESMO Open. 2021; 6(3):100114. PMC: 8095121. DOI: 10.1016/j.esmoop.2021.100114. View

10.

Grigore L, Radoi V, Serban A, Mihai A, Stoica I . The Molecular Detection of Germline Mutations in the and Genes Associated with Breast and Ovarian Cancer in a Romanian Cohort of 616 Patients. Curr Issues Mol Biol. 2024; 46(5):4630-4645. PMC: 11119367. DOI: 10.3390/cimb46050281. View

11.

Valentini V, Bucalo A, Conti G, Celli L, Porzio V, Capalbo C . Gender-Specific Genetic Predisposition to Breast Cancer: Genes and Beyond. Cancers (Basel). 2024; 16(3). PMC: 10854694. DOI: 10.3390/cancers16030579. View

12.

Ji F, Yang C, Li X, Zhang L, Yang M, Li J . Risk of breast cancer-related death in women with a prior cancer. Aging (Albany NY). 2020; 12(7):5894-5906. PMC: 7185107. DOI: 10.18632/aging.102984. View

13.

Garcia-Etienne C, Ferrari A, Della Valle A, Lucioni M, Ferraris E, Di Giulio G . Management of the axilla in patients with breast cancer and positive sentinel lymph node biopsy: An evidence-based update in a European breast center. Eur J Surg Oncol. 2019; 46(1):15-23. DOI: 10.1016/j.ejso.2019.08.013. View

14.

Angelico G, Broggi G, Tinnirello G, Puzzo L, Vecchio G, Salvatorelli L . Tumor Infiltrating Lymphocytes (TILS) and PD-L1 Expression in Breast Cancer: A Review of Current Evidence and Prognostic Implications from Pathologist's Perspective. Cancers (Basel). 2023; 15(18). PMC: 10526828. DOI: 10.3390/cancers15184479. View

15.

Restrepo D, Boczar D, Huayllani M, Sisti A, McLaughlin S, Spaulding A . Survival Disparities in Male Patients With Breast Cancer. Anticancer Res. 2019; 39(10):5669-5674. DOI: 10.21873/anticanres.13764. View

16.

Fentiman I . Surgical options for male breast cancer. Breast Cancer Res Treat. 2018; 172(3):539-544. PMC: 6245106. DOI: 10.1007/s10549-018-4952-2. View

17.

Michowitz M, Noy S, Lazebnik N, Aladjem D . Bilateral breast cancer. J Surg Oncol. 1985; 30(2):109-12. DOI: 10.1002/jso.2930300210. View

18.

Gucalp A, Traina T, Eisner J, Parker J, Selitsky S, Park B . Male breast cancer: a disease distinct from female breast cancer. Breast Cancer Res Treat. 2018; 173(1):37-48. PMC: 7513797. DOI: 10.1007/s10549-018-4921-9. View

19.

Hong J, Ha K, Jung Y, Won H, An H, Lee G . Clinical Features of Male Breast Cancer: Experiences from Seven Institutions Over 20 Years. Cancer Res Treat. 2016; 48(4):1389-1398. PMC: 5080810. DOI: 10.4143/crt.2015.410. View

20.

Varzaru V, Eftenoiu A, Vlad D, Vlad C, Moatar A, Popescu R . The Influence of Tumor-Specific Markers in Breast Cancer on Other Blood Parameters. Life (Basel). 2024; 14(4). PMC: 11051489. DOI: 10.3390/life14040458. View