Mitomycin C-induced Mosaicism in C-band Regions of Human Chromosomes 1, 9, 16, and Y

Overview

Journal Hum Genet

Specialty Genetics

Date 1985 Jan 1

PMID 3926628

Citations 1

Authors

S Simi

Affiliations

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Abstract

In order to test the hypothesis that somatic mosaicism involving C-band polymorphism of human chromosomes 1, 9, 16 may arise from mitotic crossing over, peripheral blood lymphocytes from normal males were treated with mitomycin C, which is known to induce somatic crossing over in lower eukaryotes. Evidence is presented which shows that mitomycin C is able to alter the heterochromatic pattern in human lymphocytes.

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