Allergic Bronchopulmonary Mycosis Caused by : A Case Report

Overview

Journal Respir Med Case Rep

Date 2024 Sep 12

PMID 39263247

Authors

Ryota Okazaki

Shino Arita

Hinako Hoshio

Naoki Uetani

Genki Inui

Hiroki Ishikawa

Takafumi Nonaka

Hiroki Kohno

Yoshihiro Funaki

Tomoya Harada

Masato Morita

Akira Watanabe

Akira Yamasaki

Affiliations

Soon will be listed here.

Abstract

A 61-year-old woman, hospitalized for a persistent cough and dyspnea, had no history of bronchial asthma, but was undergoing chemotherapy for methotrexate-related lymphoproliferative disorder due to rheumatoid arthritis. Her peripheral blood eosinophil count was significantly increased, and chest CT revealed left lower lobe atelectasis and high-attenuation mucus. Bronchoscopy revealed mucous plugs and pathological examination revealed numerous eosinophils and filamentous fungi. Allergic bronchopulmonary mycosis (ABPM) caused by was diagnosed using culture and genetic analyses. Treatment with corticosteroids and antifungal drugs led to improvement. ABPM caused by is extremely rare, emphasizing the importance of species identification.

References

Hoenigl M, Salmanton-Garcia J, Walsh T, Nucci M, Neoh C, Jenks J . Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for.... Lancet Infect Dis. 2021; 21(8):e246-e257. DOI: 10.1016/S1473-3099(20)30784-2. View

Tanaka Y, Imao M, Namba K, Fujimoto Y, Ikeuchi M, Yamamoto H . [A CASE OF SUSPECTED ALLERGIC BRONCHOPULMONARY MYCOSIS CAUSED BY SCEDOSPORIUM APIOSPERMUM THAT SHOWED CLINICAL IMPROVEMENT AFTER BRONCHOSCOPIC REMOVAL OF A MUCUS PLUG]. Arerugi. 2023; 72(8):1051-1056. DOI: 10.15036/arerugi.72.1051. View

Agarwal R, Aggarwal A, Dhooria S, Sehgal I, Garg M, Saikia B . A randomised trial of glucocorticoids in acute-stage allergic bronchopulmonary aspergillosis complicating asthma. Eur Respir J. 2015; 47(2):490-8. DOI: 10.1183/13993003.01475-2015. View

Bellemain E, Carlsen T, Brochmann C, Coissac E, Taberlet P, Kauserud H . ITS as an environmental DNA barcode for fungi: an in silico approach reveals potential PCR biases. BMC Microbiol. 2010; 10:189. PMC: 2909996. DOI: 10.1186/1471-2180-10-189. View

Cortez K, Roilides E, Quiroz-Telles F, Meletiadis J, Antachopoulos C, Knudsen T . Infections caused by Scedosporium spp. Clin Microbiol Rev. 2008; 21(1):157-97. PMC: 2223844. DOI: 10.1128/CMR.00039-07. View

Ishiguro T, Kagiyama N, Kojima A, Yamada M, Nakamoto Y, Takaku Y . Allergic Bronchopulmonary Mycosis Due to Schizophyllum commune Treated Effectively with Voriconazole. Intern Med. 2018; 57(17):2553-2557. PMC: 6172560. DOI: 10.2169/internalmedicine.0668-17. View

Husain S, Munoz P, Forrest G, Alexander B, Somani J, Brennan K . Infections due to Scedosporium apiospermum and Scedosporium prolificans in transplant recipients: clinical characteristics and impact of antifungal agent therapy on outcome. Clin Infect Dis. 2004; 40(1):89-99. DOI: 10.1086/426445. View

Agarwal R, Dhooria S, Sehgal I, Aggarwal A, Garg M, Saikia B . A Randomized Trial of Itraconazole vs Prednisolone in Acute-Stage Allergic Bronchopulmonary Aspergillosis Complicating Asthma. Chest. 2018; 153(3):656-664. DOI: 10.1016/j.chest.2018.01.005. View

Masunaga A, Morimoto K, Ando T, Ikushima S, Takemura T, Oritsu M . [Three cases of allergic bronchopulmonary mycosis due to Schizophyllum commune]. Nihon Kokyuki Gakkai Zasshi. 2011; 48(12):912-7. View

10.

Kaltseis J, Rainer J, de Hoog G . Ecology of Pseudallescheria and Scedosporium species in human-dominated and natural environments and their distribution in clinical samples. Med Mycol. 2008; 47(4):398-405. DOI: 10.1080/13693780802585317. View

11.

Raj R, Frost A . Scedosporium apiospermum fungemia in a lung transplant recipient. Chest. 2002; 121(5):1714-6. DOI: 10.1378/chest.121.5.1714. View

12.

Asano K, Hebisawa A, Ishiguro T, Takayanagi N, Nakamura Y, Suzuki J . New clinical diagnostic criteria for allergic bronchopulmonary aspergillosis/mycosis and its validation. J Allergy Clin Immunol. 2020; 147(4):1261-1268.e5. DOI: 10.1016/j.jaci.2020.08.029. View

13.

Ramirez-Garcia A, Pellon A, Rementeria A, Buldain I, Barreto-Bergter E, Rollin-Pinheiro R . Scedosporium and Lomentospora: an updated overview of underrated opportunists. Med Mycol. 2018; 56(suppl_1):102-125. DOI: 10.1093/mmy/myx113. View

14.

Ogawa H, Fujimura M, Takeuchi Y, Makimura K, Satoh K . The definitive diagnostic process and successful treatment for ABPM caused by Schizophyllum commune: a report of two cases. Allergol Int. 2012; 61(1):163-9. DOI: 10.2332/allergolint.11-CR-0325. View

15.

Agarwal R, Chakrabarti A, Shah A, Gupta D, Meis J, Guleria R . Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013; 43(8):850-73. DOI: 10.1111/cea.12141. View

16.

Rosenberg M, Patterson R, Mintzer R, COOPER B, Roberts M, Harris K . Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med. 1977; 86(4):405-14. DOI: 10.7326/0003-4819-86-4-405. View

17.

Kumar Singh P, Kathuria S, Agarwal K, Gaur S, Meis J, Chowdhary A . Clinical significance and molecular characterization of nonsporulating molds isolated from the respiratory tracts of bronchopulmonary mycosis patients with special reference to basidiomycetes. J Clin Microbiol. 2013; 51(10):3331-7. PMC: 3811655. DOI: 10.1128/JCM.01486-13. View

18.

Chowdhary A, Agarwal K, Kathuria S, Gaur S, Randhawa H, Meis J . Allergic bronchopulmonary mycosis due to fungi other than Aspergillus: a global overview. Crit Rev Microbiol. 2013; 40(1):30-48. DOI: 10.3109/1040841X.2012.754401. View