MiR-155 Enhances Apoptosis of Macrophage Through Suppressing PI3K-AKT Activation in Keratitis

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Sep 12

PMID 39263048

Authors

Qiang Fu

Xingyuan Zhu

Qiongyan Fang

Hui Han

Zhiying Wang

Jinye Xie

Dong Qian

Xinger Wu

Yongjian Wu

Kang Chen

Affiliations

Soon will be listed here.

Abstract

Keratitis induced by (. ) is an acute and serious corneal inflammation. As a family of gene regulators, miRNAs play a crucial role in modulating host response after microbial invasion. However, their functions in . keratitis remain largely unclear. In the present study, we demonstrated that miR-155 expression was significantly increased in macrophages and corneal tissue after . infection. studies demonstrated that mice with miR-155 knockdown displayed more resistance to keratitis, with a lower bacterial burden. In addition, and studies indicated that miR-155 enhanced apoptosis of macrophages after infection, and resulted in a susceptible phenotype of keratitis. Moreover, miR-155 induced apoptosis through reducing activation of PI3K-Akt signaling pathway. Our data provided evidence of miR-155 mediated apoptosis of macrophage in keratitis, which may be an underlying target for the therapy of keratitis and other infectious diseases.

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