Cordycepin Exhibits Both Antiviral and Anti-inflammatory Effects Against Dengue Virus Infection

Overview

Journal iScience

Publisher Cell Press

Date 2024 Sep 12

PMID 39262808

Authors

Pucharee Songprakhon

Aussara Panya

Kornkan Choomee

Thawornchai Limjindaporn

Sansanee Noisakran

Mayuri Tarasuk

Pa-Thai Yenchitsomanus

Affiliations

Soon will be listed here.

Abstract

Cordycepin, a natural derivative of adenosine from , can inhibit the replication of the dengue virus (DENV). Here, we investigated its antiviral and anti-inflammatory effects in DENV infected cells. Cordycepin significantly inhibited DENV-2 infection, virion production, and viral protein synthesis. It also reduced DENV-induced cytokine/chemokine production, including RANTES, IP-10, IL-6, and TNF-α. Mechanistically, cordycepin targeted the DENV NS5 protein, suppressing RANTES expression and hindering viral replication. Additionally, it inhibited the NF-κB pathway, leading to reduced nuclear translocation and signaling deactivation. PCR array analysis revealed cordycepin's suppression of 46 genes associated with DENV-induced inflammation. These findings highlight cordycepin's dual potential as an antiviral and anti-inflammatory agent against DENV, making it as a promising candidate for dengue treatment, targeting both viral and host factors.

Citing Articles

In Vitro Determination of Antimicrobial, Antioxidant and Antiviral Properties of Greek Plant Extracts.

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PMID: 39858945 PMC: 11767790. DOI: 10.3390/microorganisms13010177.

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