» Articles » PMID: 39262457

Fourth-generation Epidermal Growth Factor Receptor-tyrosine Kinases Inhibitors: Hope and Challenges

Overview
Specialty Oncology
Date 2024 Sep 12
PMID 39262457
Authors
Affiliations
Soon will be listed here.
References
1.
Lu X, Zhang T, Zhu S, Xun Q, Tong L, Hu X . Discovery of JND3229 as a New EGFR Mutant Inhibitor with In Vivo Monodrug Efficacy. ACS Med Chem Lett. 2018; 9(11):1123-1127. PMC: 6231186. DOI: 10.1021/acsmedchemlett.8b00373. View

2.
To C, Jang J, Chen T, Park E, Mushajiang M, De Clercq D . Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov. 2019; 9(7):926-943. PMC: 6664433. DOI: 10.1158/2159-8290.CD-18-0903. View

3.
Engelhardt H, Bose D, Petronczki M, Scharn D, Bader G, Baum A . Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors. J Med Chem. 2019; 62(22):10272-10293. DOI: 10.1021/acs.jmedchem.9b01169. View

4.
Lu X, Yu L, Zhang Z, Ren X, Smaill J, Ding K . Targeting EGFR and EGFR resistance mutations in NSCLC: Current developments in medicinal chemistry. Med Res Rev. 2018; 38(5):1550-1581. DOI: 10.1002/med.21488. View

5.
Lee D . Treatments for EGFR-mutant non-small cell lung cancer (NSCLC): The road to a success, paved with failures. Pharmacol Ther. 2017; 174:1-21. DOI: 10.1016/j.pharmthera.2017.02.001. View