Autonomic Neuromodulation for Cardiomyopathy Associated with Metabolic Syndrome - Prevention of Precursors for Heart Failure with Preserved Ejection Fraction

Overview

Journal Hypertens Res

Specialty Cardiology & Vascular Diseases

Date 2024 Sep 11

PMID 39261699

Authors

Michiaki Nagai

Karl-Philipp Rommel

Sunny S Po

Tarun W Dasari

Affiliations

Soon will be listed here.

Abstract

Metabolic syndrome (MetS) induces a systemic inflammatory state which can lead to cardiomyopathy, manifesting clinically as heart failure (HF) with preserved ejection fraction (HFpEF). MetS components are intricately linked to the pathophysiologic processes of myocardial remodeling. Increased sympathetic nervous system activity, which is noted as an upstream factor of MetS, has been linked to adverse myocardial structural changes. Since renal denervation and vagus nerve stimulation have a sympathoinhibitory effect, attention has been paid to the cardioprotective effects of autonomic neuromodulation. In this review, the pathophysiology underlying the relationship between MetS and HF is elucidated, and the evidence regarding autonomic neuromodulation in HFpEF is summarized.

Citing Articles

Cardiometabolic Index is associated with heart failure: a cross-sectional study based on NHANES.

Zhu X, Xu Y, Zhang J Front Med (Lausanne). 2024; 11:1507100.

PMID: 39717172 PMC: 11663657. DOI: 10.3389/fmed.2024.1507100.

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