Clinico-physiological Correlates of Parkinson's Disease from Multi-resolution Basal Ganglia Recordings

Overview

Journal NPJ Parkinsons Dis

Date 2024 Sep 11

PMID 39261476

Authors

Srdjan Sumarac

Jinyoung Youn

Conor Fearon

Luka Zivkovic

Prerana Keerthi

Oliver Flouty

Milos Popovic

Mojgan Hodaie

Suneil Kalia

Andres Lozano

William Hutchison

Alfonso Fasano

Luka Milosevic

Affiliations

Soon will be listed here.

Abstract

Parkinson's disease (PD) has been associated with pathological neural activity within the basal ganglia. Herein, we analyzed resting-state single-neuron and local field potential (LFP) activities from people with PD who underwent awake deep brain stimulation surgery of the subthalamic nucleus (STN; n = 125) or globus pallidus internus (GPi; n = 44), and correlated rate-based and oscillatory features with UPDRSIII off-medication subscores. Rate-based single-neuron features did not correlate with PD symptoms. STN single-neuron and LFP low-beta (12-21 Hz) power and burst dynamics showed modest correlations with bradykinesia and rigidity severity, while STN spiketrain theta (4-8 Hz) power correlated modestly with tremor severity. GPi low- and high-beta (21-30 Hz) power and burst dynamics correlated moderately with bradykinesia and axial symptom severity. These findings suggest that elevated single-neuron and LFP oscillations may be linked to symptoms, though modest correlations imply that the pathophysiology of PD may extend beyond resting-state beta oscillations.

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