Changes in Hormonal Profiles During Competition Preparation in Physique Athletes

Overview

Journal Eur J Appl Physiol

Specialty Physiology

Date 2024 Sep 11

PMID 39261323

Authors

Ville Isola

Juha J Hulmi

Theo Mbay

Heikki Kyrolainen

Keijo Hakkinen

Vilho Ahola

Eric R Helms

Juha P Ahtiainen

Affiliations

Soon will be listed here.

Abstract

Purpose: Physique athletes engage in rigorous competition preparation involving intense energy restriction and physical training to enhance muscle definition. This study investigates hormonal changes and their physiological and performance impacts during such preparation.

Methods: Participants included female (10 competing (COMP) and 10 non-dieting controls (CTRL)) and male (13 COMP and 10 CTRL) physique athletes. COMP participants were tested 23 weeks before (PRE), one week before (MID), and 23 weeks after the competition (POST). Non-dieting CTRL participants were tested at similar intervals. Measurements included body composition (DXA), muscle cross-sectional area (ultrasound), energy availability (EA) derived by subtracting exercise energy expenditure (EEE) from energy intake (EI) and dividing by fat-free mass (FFM), muscle strength, and various serum hormone concentrations (ACTH, cortisol, estradiol, FSH, IGF-1, IGFBP-3, insulin, and free and total testosterone and SHBG).

Results: During the diet, EA (p < 0.001), IGF-1 (p < 0.001), IGFBP-3 (p < 0.01), and absolute muscle strength (p < 0.01-0.001) decreased significantly in both sexes in COMP. Decreases in IGF-1 were also associated with higher loss in FFM. In males, testosterone (p < 0.01) and free testosterone (p < 0.05) decreased, while SHBG (p < 0.001) and cortisol (p < 0.05) increased. Insulin decreased significantly only in males (p < 0.001). Mood disturbances, particularly increased fatigue in males (p < 0.05), highlighted the psychological strain of competition preparation. All these changes were restored by increased EA during the post-competition recovery period.

Conclusion: Significant reductions in IGF-1 and IGFBP-3 during competition preparation may serve as biomarkers for monitoring physiological stress. This study offers valuable insights into hormonal changes, muscle strength, and mood state during energy-restricted intense training.

References

Ihle R, Loucks A . Dose-response relationships between energy availability and bone turnover in young exercising women. J Bone Miner Res. 2004; 19(8):1231-40. DOI: 10.1359/JBMR.040410. View

Henning P, Scofield D, Spiering B, Staab J, Matheny Jr R, Smith M . Recovery of endocrine and inflammatory mediators following an extended energy deficit. J Clin Endocrinol Metab. 2014; 99(3):956-64. DOI: 10.1210/jc.2013-3046. View

Mitchell L, Slater G, Hackett D, Johnson N, OConnor H . Physiological implications of preparing for a natural male bodybuilding competition. Eur J Sport Sci. 2018; 18(5):619-629. DOI: 10.1080/17461391.2018.1444095. View

Carey J, Delaney M, Love T, Richmond B, Cromer B, Miller P . DXA-generated Z-scores and T-scores may differ substantially and significantly in young adults. J Clin Densitom. 2007; 10(4):351-8. DOI: 10.1016/j.jocd.2007.06.001. View

Schoenfeld B, Androulakis-Korakakis P, Pinero A, Burke R, Coleman M, Mohan A . Alterations in Measures of Body Composition, Neuromuscular Performance, Hormonal Levels, Physiological Adaptations, and Psychometric Outcomes during Preparation for Physique Competition: A Systematic Review of Case Studies. J Funct Morphol Kinesiol. 2023; 8(2). PMC: 10204542. DOI: 10.3390/jfmk8020059. View

Hakkinen K, Pakarinen A, Kallinen M . Neuromuscular adaptations and serum hormones in women during short-term intensive strength training. Eur J Appl Physiol Occup Physiol. 1992; 64(2):106-11. DOI: 10.1007/BF00717946. View

Jones E, Bishop P, Woods A, Green J . Cross-sectional area and muscular strength: a brief review. Sports Med. 2008; 38(12):987-94. DOI: 10.2165/00007256-200838120-00003. View

Vuoskoski J, Eerola T . The role of mood and personality in the perception of emotions represented by music. Cortex. 2011; 47(9):1099-106. DOI: 10.1016/j.cortex.2011.04.011. View

Healy M, Gibney J, Pentecost C, Wheeler M, Sonksen P . Endocrine profiles in 693 elite athletes in the postcompetition setting. Clin Endocrinol (Oxf). 2014; 81(2):294-305. DOI: 10.1111/cen.12445. View

10.

Hakkinen K, Newton R, Walker S, Hakkinen A, Krapi S, Rekola R . Effects of Upper Body Eccentric versus Concentric Strength Training and Detraining on Maximal Force, Muscle Activation, Hypertrophy and Serum Hormones in Women. J Sports Sci Med. 2022; 21(2):200-213. PMC: 9157521. DOI: 10.52082/jssm.2022.200. View

11.

Heikura I, Uusitalo A, Stellingwerff T, Bergland D, Mero A, Burke L . Low Energy Availability Is Difficult to Assess but Outcomes Have Large Impact on Bone Injury Rates in Elite Distance Athletes. Int J Sport Nutr Exerc Metab. 2017; 28(4):403-411. DOI: 10.1123/ijsnem.2017-0313. View

12.

Maestu J, Eliakim A, Jurimae J, Valter I, Jurimae T . Anabolic and catabolic hormones and energy balance of the male bodybuilders during the preparation for the competition. J Strength Cond Res. 2010; 24(4):1074-81. DOI: 10.1519/JSC.0b013e3181cb6fd3. View

13.

Hakkinen K, Pakarinen A, Alen M, Kauhanen H, Komi P . Relationships between training volume, physical performance capacity, and serum hormone concentrations during prolonged training in elite weight lifters. Int J Sports Med. 1987; 8 Suppl 1:61-5. DOI: 10.1055/s-2008-1025705. View

14.

Ainsworth B, Haskell W, Whitt M, Irwin M, Swartz A, Strath S . Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000; 32(9 Suppl):S498-504. DOI: 10.1097/00005768-200009001-00009. View

15.

Robinson S, Lambeth-Mansell A, Gillibrand G, Smith-Ryan A, Bannock L . A nutrition and conditioning intervention for natural bodybuilding contest preparation: case study. J Int Soc Sports Nutr. 2015; 12:20. PMC: 4422265. DOI: 10.1186/s12970-015-0083-x. View

16.

Longstrom J, Colenso-Semple L, Waddell B, Mastrofini G, Trexler E, Campbell B . Physiological, Psychological and Performance-Related Changes Following Physique Competition: A Case-Series. J Funct Morphol Kinesiol. 2021; 5(2). PMC: 7739261. DOI: 10.3390/jfmk5020027. View

17.

Williams R, Wood L, Collins C, Callister R . Effectiveness of weight loss interventions--is there a difference between men and women: a systematic review. Obes Rev. 2014; 16(2):171-86. PMC: 4359685. DOI: 10.1111/obr.12241. View

18.

Karila T, Sarkkinen P, Marttinen M, Seppala T, Mero A, Tallroth K . Rapid weight loss decreases serum testosterone. Int J Sports Med. 2008; 29(11):872-7. DOI: 10.1055/s-2008-1038604. View

19.

Isola V, Hulmi J, Petaja P, Helms E, Karppinen J, Ahtiainen J . Weight loss induces changes in adaptive thermogenesis in female and male physique athletes. Appl Physiol Nutr Metab. 2023; 48(4):307-320. DOI: 10.1139/apnm-2022-0372. View

20.

Nindl B, Barnes B, Alemany J, Frykman P, Shippee R, Friedl K . Physiological consequences of U.S. Army Ranger training. Med Sci Sports Exerc. 2007; 39(8):1380-7. DOI: 10.1249/MSS.0b013e318067e2f7. View