Effects of Hydrogen-rich Water on Blood Uric Acid in Patients with Hyperuricemia: A Randomized Placebo-controlled Trial

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Sep 11

PMID 39258191

Authors

Fenglin Wu

Jun Ma

Junli Xue

Xue Jiang

Jinyu Liu

Jiashuo Zhang

Yazhuo Xue

Boyan Liu

Shucun Qin

Affiliations

Soon will be listed here.

Abstract

Background: Consumption of hydrogen-rich water (HRW) has been shown to have anti-inflammatory and metabolic-modulatory benefits.

Objective: A randomized, placebo-controlled trial was conducted to assess the potential blood uric acid-lowering effects of HRW consumption with different doses (low and high doses) and duration (4 and 8 weeks) in patients with hyperuricemia.

Methods: The Placebo group consumed three bottles of ordinary drinking water (330 mL per bottle), the Low-HRW group consumed two bottles of HRW (330 mL per bottle, H ≥ 4.66 mg/L) and a bottle of ordinary water, and the High-HRW group consumed three bottles of HRW daily for 8 weeks. The primary outcome was the blood uric acid levels following different time points (4 and 8 weeks) compared to baseline.

Results: A total of 100 participants completed the entire trial (32 in Placebo, 35 in Low-HRW, and 33 in High-HRW groups). The high-dose of HRW was more effective than low-dose HRW in controlling blood uric acid. Following an 8-week period, the High-HRW group exhibited a significant reduction in blood uric acid levels compared to the baseline (488.2 ± 54.1 μmol/L to 446.8 ± 57.1 μmol/L, < 0.05).

Conclusion: As a rather safe agent, the prolonged consumption of HRW may be feasible in the management of hyperuricemia.

Clinical Trial Registration: chictr.org.cn, identifier ChiCTR2200066369.

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