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Histamine Reduces the Deamination of Putrescine in Vitro--but Also in Vivo?

Overview
Journal Agents Actions
Specialty Pharmacology
Date 1985 Apr 1
PMID 3925731
Citations 2
Authors
J Kusche
R Mennigen
I Rosenthal
Affiliations
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Abstract

The diamine oxidase catalysed deamination of putrescine was reduced in vitro by histamine at concentrations occurring in the gut. An oral application of histamine, however, had no effect on the enzymic activity. When the histamine was injected i.p. a decrease of intestinal diamine oxidase activity was observed which, however, did not depend on histamine but probably on an unspecific irritation of the gut.

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Histamine content, diamine oxydase and histidine decarboxylase activities along the intestinal tract of the rat.

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Histaminase activity in rat lung and its comparison with intestinal mucosal diamine oxidase.

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