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The Fracture Phenotypes in Women and Men of 50 Years and Older with a Recent Clinical Fracture

Overview
Publisher Current Science
Date 2024 Sep 10
PMID 39254815
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Abstract

Purpose Of Review: We review the literature about patients 50 years and older with a recent clinical fracture for the presence of skeletal and extra-skeletal risks, their perspectives of imminent subsequent fracture, falls, mortality, and other risks, and on the role of the fracture liaison service (FLS) for timely secondary fracture prevention.

Recent Findings: Patients with a recent clinical fracture present with heterogeneous patterns of bone-, fall-, and comorbidity-related risks. Short-term perspectives include bone loss, increased risk of fractures, falls, and mortality, and a decrease in physical performance and quality of life. Combined evaluation of bone, fall risk, and the presence of associated comorbidities contributes to treatment strategies. Since fractures are related to interactions of bone-, fall-, and comorbidity-related risks, there is no one-single-discipline-fits-all approach but a need for a multidisciplinary approach at the FLS to consider all phenotypes for evaluation and treatment in an individual patient.

References
1.
Fuggle N, Beaudart C, Bruyere O, Abrahamsen B, Al-Daghri N, Burlet N . Evidence-Based Guideline for the management of osteoporosis in men. Nat Rev Rheumatol. 2024; 20(4):241-251. DOI: 10.1038/s41584-024-01094-9. View

2.
Schini M, Johansson H, Harvey N, Lorentzon M, Kanis J, McCloskey E . An overview of the use of the fracture risk assessment tool (FRAX) in osteoporosis. J Endocrinol Invest. 2023; 47(3):501-511. PMC: 10904566. DOI: 10.1007/s40618-023-02219-9. View

3.
Javaid M, Pinedo-Villanueva R, Shah A, Mohsin Z, Hiligsmann M, Motek-Soulie A . The Capture the Fracture® Partnership: an overview of a global initiative to increase the secondary fracture prevention care for patient benefit. Osteoporos Int. 2023; 34(11):1827-1835. PMC: 10579122. DOI: 10.1007/s00198-023-06759-x. View

4.
Leslie W, Schousboe J, Morin S, Martineau P, Lix L, Johansson H . Fracture risk following high-trauma versus low-trauma fracture: a registry-based cohort study. Osteoporos Int. 2020; 31(6):1059-1067. PMC: 7115893. DOI: 10.1007/s00198-019-05274-2. View

5.
Barron R, Oster G, Grauer A, Crittenden D, Weycker D . Determinants of imminent fracture risk in postmenopausal women with osteoporosis. Osteoporos Int. 2020; 31(11):2103-2111. PMC: 7560920. DOI: 10.1007/s00198-020-05294-3. View