From Mesenchymal Stem Cells to Their Extracellular Vesicles: Progress and Prospects for Asthma Therapy

Overview

Journal Asian J Pharm Sci

Date 2024 Sep 10

PMID 39253613

Authors

Shihan Chen

Jianqing Gao

Tianyuan Zhang

Affiliations

Soon will be listed here.

Abstract

Asthma is a widespread public health concern, with an increasing incidence. Despite the implementation of current treatment strategies, asthma control, particularly for severe cases, remains suboptimal. Recent research has revealed the encouraging prospects of extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) as a viable therapeutic option for alleviating asthma symptoms. Therefore, the present review aims to provide an overview of the current progress and the therapeutic mechanisms of using MSC-derived EVs (MSC-EVs) for asthma treatment. Additionally, different administration approaches for EVs and their impacts on biodistribution and the curative outcomes of EVs are summarized. Notably, the potential benefits of nebulized inhalation of MSC-EVs are addressed. Also, the possibilities and challenges of using MSC-EVs for asthma treatment in clinics are highlighted. Overall, this review is intended to give new insight into the utilization of MSC-EVs as a potential biological drug for asthma treatment.

References

Dong L, Wang Y, Zheng T, Pu Y, Ma Y, Qi X . Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice. Stem Cell Res Ther. 2021; 12(1):4. PMC: 7789736. DOI: 10.1186/s13287-020-02072-0. View

Peng Y, Deng X, Xu Z, Wu Z, Fu Q . Mesenchymal stromal cells and their small extracellular vesicles in allergic diseases: From immunomodulation to therapy. Eur J Immunol. 2023; 53(10):e2149510. DOI: 10.1002/eji.202149510. View

Kaminsky D, Chapman D . Asthma and Lung Mechanics. Compr Physiol. 2020; 10(3):975-1007. DOI: 10.1002/cphy.c190020. View

Zhu Y, Shi M, Monsel A, Dai C, Dong X, Shen H . Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID-19: a pilot study. Stem Cell Res Ther. 2022; 13(1):220. PMC: 9135389. DOI: 10.1186/s13287-022-02900-5. View

Agache I, Rocha C, Beltran J, Song Y, Posso M, Sola I . Efficacy and safety of treatment with biologicals (benralizumab, dupilumab and omalizumab) for severe allergic asthma: A systematic review for the EAACI Guidelines - recommendations on the use of biologicals in severe asthma. Allergy. 2020; 75(5):1043-1057. DOI: 10.1111/all.14235. View

Sobieraj D, Weeda E, Nguyen E, Coleman C, White C, Lazarus S . Association of Inhaled Corticosteroids and Long-Acting β-Agonists as Controller and Quick Relief Therapy With Exacerbations and Symptom Control in Persistent Asthma: A Systematic Review and Meta-analysis. JAMA. 2018; 319(14):1485-1496. PMC: 5876810. DOI: 10.1001/jama.2018.2769. View

Takahashi Y, Nishikawa M, Shinotsuka H, Matsui Y, Ohara S, Imai T . Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection. J Biotechnol. 2013; 165(2):77-84. DOI: 10.1016/j.jbiotec.2013.03.013. View

Ng C, Mohamed Sharif A, Heath D, Chow J, Zhang C, Chan-Park M . Enhanced ex vivo expansion of adult mesenchymal stem cells by fetal mesenchymal stem cell ECM. Biomaterials. 2014; 35(13):4046-57. DOI: 10.1016/j.biomaterials.2014.01.081. View

Naji A, Eitoku M, Favier B, Deschaseaux F, Rouas-Freiss N, Suganuma N . Biological functions of mesenchymal stem cells and clinical implications. Cell Mol Life Sci. 2019; 76(17):3323-3348. PMC: 11105258. DOI: 10.1007/s00018-019-03125-1. View

10.

Josefowicz S, Lu L, Rudensky A . Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 2012; 30:531-64. PMC: 6066374. DOI: 10.1146/annurev.immunol.25.022106.141623. View

11.

Camussi G, Deregibus M, Cantaluppi V . Role of stem-cell-derived microvesicles in the paracrine action of stem cells. Biochem Soc Trans. 2013; 41(1):283-7. DOI: 10.1042/BST20120192. View

12.

Phinney D, Di Giuseppe M, Njah J, Sala E, Shiva S, St Croix C . Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs. Nat Commun. 2015; 6:8472. PMC: 4598952. DOI: 10.1038/ncomms9472. View

13.

Newman S . Delivering drugs to the lungs: The history of repurposing in the treatment of respiratory diseases. Adv Drug Deliv Rev. 2018; 133:5-18. DOI: 10.1016/j.addr.2018.04.010. View

14.

Zhang J, Lin R, Li Y, Wang J, Ding H, Fang P . A large-scale production of mesenchymal stem cells and their exosomes for an efficient treatment against lung inflammation. Biotechnol J. 2024; 19(2):e2300174. DOI: 10.1002/biot.202300174. View

15.

Lazaro-Ibanez E, Faruqu F, Saleh A, Silva A, Wang J, Rak J . Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution . ACS Nano. 2021; 15(2):3212-3227. PMC: 7905875. DOI: 10.1021/acsnano.0c09873. View

16.

Zheng J, Lu T, Zhou C, Cai J, Zhang X, Liang J . Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Protect Liver Ischemia/Reperfusion Injury by Reducing CD154 Expression on CD4+ T Cells via CCT2. Adv Sci (Weinh). 2020; 7(18):1903746. PMC: 7509664. DOI: 10.1002/advs.201903746. View

17.

Latifkar A, Hur Y, Sanchez J, Cerione R, Antonyak M . New insights into extracellular vesicle biogenesis and function. J Cell Sci. 2019; 132(13). PMC: 6633391. DOI: 10.1242/jcs.222406. View

18.

Banno A, Reddy A, Lakshmi S, Reddy R . Bidirectional interaction of airway epithelial remodeling and inflammation in asthma. Clin Sci (Lond). 2020; 134(9):1063-1079. DOI: 10.1042/CS20191309. View

19.

Badi Y, Salcman B, Taylor A, Rana B, Kermani N, Riley J . IL1RAP expression and the enrichment of IL-33 activation signatures in severe neutrophilic asthma. Allergy. 2022; 78(1):156-167. PMC: 10086999. DOI: 10.1111/all.15487. View

20.

Patton J, Fishburn C, Weers J . The lungs as a portal of entry for systemic drug delivery. Proc Am Thorac Soc. 2005; 1(4):338-44. DOI: 10.1513/pats.200409-049TA. View