Correcting an Immune-response Deficiency by Creating E Alpha Gene Transgenic Mice

Overview

Journal Nature

Specialty Science

Date 1985 Jul 4

PMID 3925351

Citations 46

Authors

M Le Meur

P Gerlinger

C Benoist

D Mathis

Affiliations

Soon will be listed here.

Abstract

We have introduced a cloned Ek alpha gene into embryos of mice incapable of expressing their endogenous E alpha genes. The transcription of Ek alpha was accurate and tissue-specific in the resulting transgenic lines and, in macrophages, Ek alpha transcription could be induced by gamma-interferon. The injected gene conferred on the genetically deficient host strain the ability to mount an immune response to a synthetic polymer.

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