MiR-19a-3p Promotes the Growth of Hepatocellular Carcinoma by Regulating P53/SOX4

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Sep 10

PMID 39253193

Authors

Hang Zhang

Jiajun Zhu

Jingjun Zhang

Ying Liu

Baicheng Zhao

Xiaoyi Yang

Wenhan Zhou

Bozhou Chen

Shuangshuang Zhang

Ruotong Huang

Shuying Chen

Affiliations

Soon will be listed here.

Abstract

Objective: This study aims to investigate the potential functions of miR-19a-3p in HCC.

Method: We collected serum samples to analyze miR-19a-3p expression. We utilized CCK8 and Transwell assays to access miR-19a-3p's influence on HCC cells malignancy. We used dual-luciferase reporter and western blotting to validate the impact of p53/miR-19 on miR-19/SOX4.

Results: The results demonstrated that miR-19a-3p was highly expressed in pre-operative serum samples and HCC cells, which can promote cell proliferation, migration and invasion in HCC under conditions. Additionally, there was a p53 binding site on the upstream of miR-19a-3p, which was inhibited by p53. SOX4 was the direct gene targeted by miR-19a-3p. The imbalance of p53-miR-19-SOX4 loop was one reason for the progress of HCC.

Conclusion: Our findings validate the mechanisms of miR-19a-3p and highlight its potential as a therapeutic target in HCC.

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