Advances in Application of Hypoxia-preconditioned Mesenchymal Stem Cell-derived Exosomes

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2024 Sep 6

PMID 39239560

Authors

Haitao Zhuo

Yunfei Chen

Guifang Zhao

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cells (MSCs) primarily secrete physiologically functional exosomes via paracrine effects that act on various adjacent and distant cells, thus exerting their therapeutic effects. In recent years, hypoxic preconditioning, as a novel MSC culture mode, has emerged as a research hotspot. Many previous studies have shown the role and underlying regulatory mechanisms of hypoxic preconditioning in various diseases, which has provided sufficient reference materials for the MSC research field. Therefore, this review summarizes the progress in application of hypoxia-preconditioned MSC-derived exosomes that substantially increases and improves the biological activity of specific molecules, such as microRNA.

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