Metal-free Approach for Imidazole Synthesis One-pot -α-C(sp)- Bond Functionalization of Benzylamines

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2024 Sep 6

PMID 39239291

Authors

Vikas D Kadu

Machhindra S Thokal

Rajkumar K Godase

Bhagyashree C Kotali

Pooja S Wadkar

Affiliations

Soon will be listed here.

Abstract

A metal-free one-pot method is established for the synthesis of tetrasubstituted imidazoles from the reaction of arylmethylamines and 1,2-dicarbonyls/benzoin. The -α-C(sp)- bond functionalization of arylmethylamines using a catalytic amount of AcOH afforded polysubstituted imidazoles under aerobic conditions in significant yields of up to 95%.

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