Mussel-inspired Sulfated Hyaluronan Cryogel Patch with Antioxidant, Anti-inflammatory, and Drug-loading Properties for Multifunctional Wound Adhesives

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2024 Sep 6

PMID 39239260

Authors

Wonmoon Song

Young Hwan Choi

Young Gi Moon

Changyub Lee

M Nivedhitha Sundaram

Nathaniel S Hwang

Affiliations

Soon will be listed here.

Abstract

Wounds, characterized by the disruption of the continuity of body tissues resulting from external trauma, manifest in diverse types and locations. Although numerous wound dressings are available for various wound scenarios, it remains challenging to find an integrative wound dressing capable of addressing diverse wound situations. We focused on utilizing sulfated hyaluronan (sHA), known for its anti-inflammatory properties and capacity to load cationic drugs. By conjugating catechol groups to sHA (sHA-CA), we achieved several advantages in wound healing: 1) Fabrication of patches through crosslinking with catechol-modified high-molecular-weight hyaluronan (HA(HMW)-CA), 2) Adhesiveness that enabled stable localization, 3) Radical scavenging that could synergize with the immunomodulation of sHA. The sHA-CA patches demonstrated therapeutic efficacy in three distinct murine wound models: diabetic wound, hepatic hemorrhage, and post-surgical adhesion. Collectively, these findings underscore the potential of the sHA-CA patch as a promising candidate for the next-generation wound dressing.

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