Chemical Burn Wounds As a Risk Factor for Gastric Cancer: In-silico Analyses-experimental Research

Overview

Journal Ann Med Surg (Lond)

Publisher Wolters Kluwer

Specialty Medical Education

Date 2024 Sep 6

PMID 39239032

Authors

Mohammad Reza Zabihi

Mohammad Akhoondian

Mobina Tohidian

Samad Karkhah

Pooyan Ghorbani Vajargah

Seyed Amirhossein Mazhari

Bahar Farhadi

Ramyar Farzan

Affiliations

Soon will be listed here.

Abstract

Introduction: The present study employs bioinformatics tools to identify shared upregulated genes between chemical burns and gastric cancer.

Methods: Gene Expression Omnibus (GEO) retrieved gene sets for this investigation. GSEs with value less than 0.05 and LOG fold change (FC) greater than 1 were valid and upregulated. Gastric cancer and chemical burn common elevated genes were found using Venn diagram online tools. In the second stage, the "string" visualized gastric cancer elevated genes network, and non-coding RNAs were deleted, and "interaction" greater than 1 was examined to choose important gene nodes. Next, they explored the String gene-interaction network for common genes. To determine the most interacting genes, Gephi (V 0.9.7) used "betweenness centrality" greater than "0" to evaluate the twenty-gene network. TISIDB and drug banks provide gene-related medications.

Results: In the present study, two genes, including ALOX5AP and SERPINB2, were obtained, with the highest centrality among chemical burns and gastric cancer shared genes. Additionally, the current study presented five drugs, including Urokinase, Tenecteplase, DG031, AM103, and Fiboflapon, which can have predicted effects on gastric cancer following chemical burns.

Conclusion: According to current in-silicon analyses, ALOX5AP and SERPINB2 are linked genetic keys between gastric chemical burn and cancer. Considering that burn is an environmental factor that leads to the upregulation of the two genes thus, the chemical burn can be related to the incidence of gastric cancer.

References

Grant C, Kyprianou N . Epithelial mesenchymal transition (EMT) in prostate growth and tumor progression. Transl Androl Urol. 2014; 2(3):202-211. PMC: 4208065. DOI: 10.3978/j.issn.2223-4683.2013.09.04. View

Mobayen M, Feizkhah A, Ghazanfari M, Ezzati K, Mehrabian F, Toolaroud P . Sexual satisfaction among women with severe burns. Burns. 2022; 48(6):1518-1519. DOI: 10.1016/j.burns.2022.05.024. View

Miri S, Hosseini S, Ghorbani Vajargah P, Firooz M, Takasi P, Mollaei A . Effects of massage therapy on pain and anxiety intensity in patients with burns: A systematic review and meta-analysis. Int Wound J. 2023; 20(6):2440-2458. PMC: 10333016. DOI: 10.1111/iwj.14089. View

Van Loey N, van Son M . Psychopathology and psychological problems in patients with burn scars: epidemiology and management. Am J Clin Dermatol. 2003; 4(4):245-72. DOI: 10.2165/00128071-200304040-00004. View

Farzan R, Parvizi A, Haddadi S, Tabarian M, Jamshidbeigi A, Samidoust P . Effects of non-pharmacological interventions on pain intensity of children with burns: A systematic review and meta-analysis. Int Wound J. 2023; 20(7):2898-2913. PMC: 10410361. DOI: 10.1111/iwj.14134. View

Alfano D, Franco P, Vocca I, Gambi N, Pisa V, Mancini A . The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis. Thromb Haemost. 2005; 93(2):205-11. DOI: 10.1160/TH04-09-0592. View

Vakili Ojarood M, Yaghoubi T, Mohsenizadeh S, Torabi H, Farzan R . The future of burn management: How can machine learning lead to a revolution in improving the rehabilitation of burn patients?. Burns. 2024; 50(6):1704-1706. DOI: 10.1016/j.burns.2024.03.008. View

Rangraz Jeddi F, Nabovati E, Mobayen M, Akbari H, Feizkhah A, Motalebi Kashani M . A Smartphone Application for Caregivers of Children With Severe Burns: A Survey to Identify Minimum Data Set and Requirements. J Burn Care Res. 2023; 44(5):1200-1207. DOI: 10.1093/jbcr/irad027. View

Croucher D, Saunders D, Lobov S, Ranson M . Revisiting the biological roles of PAI2 (SERPINB2) in cancer. Nat Rev Cancer. 2008; 8(7):535-45. DOI: 10.1038/nrc2400. View

10.

Mobayen M, Ghazanfari M, Hosseini S, Firooz M, Ghorbani Vajargah P, Mollaei A . Near-death experiences of burn survivors: An important yet challenging issue. Burns. 2023; 49(6):1482-1483. DOI: 10.1016/j.burns.2023.05.006. View

11.

Keh S, Onyekwelu N, McManus K, McGuigan J . Corrosive injury to upper gastrointestinal tract: Still a major surgical dilemma. World J Gastroenterol. 2006; 12(32):5223-8. PMC: 4088025. DOI: 10.3748/wjg.v12.i32.5223. View

12.

Farzan R, Moeinian M, Abdollahi A, Jahangard-Rafsanjani Z, Alipour A, Ebrahimi M . Effects of amniotic membrane extract and deferoxamine on angiogenesis in wound healing: an in vivo model. J Wound Care. 2018; 27(Sup6):S26-S32. DOI: 10.12968/jowc.2018.27.Sup6.S26. View

13.

Macgregor F . Facial disfigurement: problems and management of social interaction and implications for mental health. Aesthetic Plast Surg. 1990; 14(4):249-57. DOI: 10.1007/BF01578358. View

14.

Bazzi A, Ghazanfari M, Norouzi M, Mobayen M, Jafaraghaee F, Emami Zeydi A . Adherence to Referral Criteria for Burn Patients; a Systematic Review. Arch Acad Emerg Med. 2022; 10(1):e43. PMC: 9206830. DOI: 10.22037/aaem.v10i1.1534. View

15.

Baradaran-Rafii A, Eslani M, Haq Z, Shirzadeh E, Huvard M, Djalilian A . Current and Upcoming Therapies for Ocular Surface Chemical Injuries. Ocul Surf. 2016; 15(1):48-64. PMC: 5191942. DOI: 10.1016/j.jtos.2016.09.002. View

16.

Mobayen M, Torabi H, Toolaroud P, Tolouei M, Dehnadi Moghadam A, Saadatmand M . Acute burns during the COVID-19 pandemic: A one-year retrospective study of 611 patients at a referral burn centre in northern Iran. Int Wound J. 2023; 20(8):3204-3211. PMC: 10502268. DOI: 10.1111/iwj.14199. View

17.

Akhoondian M, Zabihi M, Yavari S, Karampoor M, Fouladpour A, Samadnia A . Burns may be a risk factor for endometriosis. Burns. 2022; 49(2):476-480. DOI: 10.1016/j.burns.2022.08.013. View

18.

Niumanlan , Jingming Y, Hao Q, Farzan R, Alizadeh Otaghvar H . A systematic review of the exercise effects on burn wound healing. Int Wound J. 2023; 21(3):e14482. PMC: 10898404. DOI: 10.1111/iwj.14482. View

19.

Mobayen M, Ghazanfari M, Feizkhah A, Ezzati K, Mehrabian F, Aboutaleb E . Parental adjustment after pediatric burn injury. Burns. 2022; 48(6):1520-1521. DOI: 10.1016/j.burns.2022.05.021. View

20.

Farzan R, Hosseini S, Firooz M, Tabarian M, Jamshidbeigi A, Samidoust P . Perceived stigmatisation and reliability of questionnaire in the survivors with burns wound: A systematic review and meta-analysis. Int Wound J. 2023; 20(8):3391-3403. PMC: 10502297. DOI: 10.1111/iwj.14176. View