Bibliometric Analysis of Research on Gut Microbiota and Bile Acids: Publication Trends and Research Frontiers

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2024 Sep 5

PMID 39234549

Authors

Xin Li

Can Lu

Xue Mao

Jiahong Fan

Jianting Yao

Jingjie Jiang

Lele Wu

Jingjing Ren

Jun Shen

Affiliations

Soon will be listed here.

Abstract

The gut microbiota is widely regarded as a "metabolic organ" that could generate myriad metabolites to regulate human metabolism. As the microbiota metabolites, bile acids (BAs) have recently been identified as the critical endocrine molecules that mediate the cross-talk between the host and intestinal microbiota. This study provided a comprehensive insight into the gut microbiota and BA research through bibliometric analysis from 2003 to 2022. The publications on this subject showed a dramatic upward trend. Although the USA and China have produced the most publications, the USA plays a dominant role in this expanding field. Specifically, the University of Copenhagen was the most productive institution. Key research hotspots are the gut-liver axis, short-chain fatty acids (SCFAs), cardiovascular disease (CVD), colorectal cancer (CRC), and the farnesoid x receptor (FXR). The molecular mechanisms and potential applications of the gut microbiota and BAs in cardiometabolic disorders and gastrointestinal cancers have significant potential for further research.

References

Mayerhofer C, Ueland T, Broch K, Vincent R, Cross G, Dahl C . Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure. J Card Fail. 2017; 23(9):666-671. DOI: 10.1016/j.cardfail.2017.06.007. View

Li H, Shen J, Wu T, Kuang J, Liu Q, Cheng S . Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis. Front Pharmacol. 2019; 10:548. PMC: 6546903. DOI: 10.3389/fphar.2019.00548. View

Krautkramer K, Fan J, Backhed F . Gut microbial metabolites as multi-kingdom intermediates. Nat Rev Microbiol. 2020; 19(2):77-94. DOI: 10.1038/s41579-020-0438-4. View

den Besten G, van Eunen K, Groen A, Venema K, Reijngoud D, Bakker B . The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res. 2013; 54(9):2325-40. PMC: 3735932. DOI: 10.1194/jlr.R036012. View

Anselmi G, Gagliardi L, Egidi G, Leone S, Gasbarrini A, Miggiano G . Gut Microbiota and Cardiovascular Diseases: A Critical Review. Cardiol Rev. 2020; 29(4):195-204. DOI: 10.1097/CRD.0000000000000327. View

Sinha S, Haileselassie Y, Nguyen L, Tropini C, Wang M, Becker L . Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation. Cell Host Microbe. 2020; 27(4):659-670.e5. PMC: 8172352. DOI: 10.1016/j.chom.2020.01.021. View

Ling L, Ouyang Y, Hu Y . Research trends on nanomaterials in gastric cancer: a bibliometric analysis from 2004 to 2023. J Nanobiotechnology. 2023; 21(1):248. PMC: 10394877. DOI: 10.1186/s12951-023-02033-8. View

Ma C, Han M, Heinrich B, Fu Q, Zhang Q, Sandhu M . Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells. Science. 2018; 360(6391). PMC: 6407885. DOI: 10.1126/science.aan5931. View

Ferslew B, Xie G, Johnston C, Su M, Stewart P, Jia W . Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis. Dig Dis Sci. 2015; 60(11):3318-28. PMC: 4864493. DOI: 10.1007/s10620-015-3776-8. View

10.

Pluznick J, Protzko R, Gevorgyan H, Peterlin Z, Sipos A, Han J . Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci U S A. 2013; 110(11):4410-5. PMC: 3600440. DOI: 10.1073/pnas.1215927110. View

11.

Kuhn T, Stepien M, Lopez-Nogueroles M, Damms-Machado A, Sookthai D, Johnson T . Prediagnostic Plasma Bile Acid Levels and Colon Cancer Risk: A Prospective Study. J Natl Cancer Inst. 2019; 112(5):516-524. PMC: 7225675. DOI: 10.1093/jnci/djz166. View

12.

Turnbaugh P, Ley R, Mahowald M, Magrini V, Mardis E, Gordon J . An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444(7122):1027-31. DOI: 10.1038/nature05414. View

13.

Sayin S, Wahlstrom A, Felin J, Jantti S, Marschall H, Bamberg K . Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013; 17(2):225-35. DOI: 10.1016/j.cmet.2013.01.003. View

14.

Shanahan F, Ghosh T, OToole P . The Healthy Microbiome-What Is the Definition of a Healthy Gut Microbiome?. Gastroenterology. 2020; 160(2):483-494. DOI: 10.1053/j.gastro.2020.09.057. View

15.

Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk T, Grefhorst A, Abdelkarim M . The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem. 2006; 281(16):11039-49. DOI: 10.1074/jbc.M510258200. View

16.

Tang Y, Chen Y, Jiang H, Robbins G, Nie D . G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer. Int J Cancer. 2010; 128(4):847-56. DOI: 10.1002/ijc.25638. View

17.

Wu H, Tremaroli V, Backhed F . Linking Microbiota to Human Diseases: A Systems Biology Perspective. Trends Endocrinol Metab. 2015; 26(12):758-770. DOI: 10.1016/j.tem.2015.09.011. View

18.

de Boer J, Schonewille M, Boesjes M, Wolters H, Bloks V, Bos T . Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice. Gastroenterology. 2017; 152(5):1126-1138.e6. DOI: 10.1053/j.gastro.2016.12.037. View

19.

Kakiyama G, Pandak W, Gillevet P, Hylemon P, Heuman D, Daita K . Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. J Hepatol. 2013; 58(5):949-55. PMC: 3936319. DOI: 10.1016/j.jhep.2013.01.003. View

20.

Liu X, Zhang X, Ji L, Gu J, Zhou M, Chen S . Farnesoid X receptor associates with β-catenin and inhibits its activity in hepatocellular carcinoma. Oncotarget. 2015; 6(6):4226-38. PMC: 4414185. DOI: 10.18632/oncotarget.2899. View