Overexpression of Long Non-coding RNAs and Predict Poor Prognosis in Patients with Gastric Adenocarcinoma

Overview

Journal Adv Biomed Res

Specialty Biomedical Engineering

Date 2024 Sep 5

PMID 39234433

Authors

Mahdi Bagheri

Safieh Aghaabdollahian

Milad Asghardoust Rezaei

Ali Mehdi Gholian Kholerdi

Mehdi Raei

Mohammad Keyvanloo Shahrestanaki

Affiliations

Soon will be listed here.

Abstract

Background: LINC00092 and MCM3AP-AS1 long non-coding RNAs (LncRNAs) play significant roles in the development and pathogenesis of many cancers. However, their expression levels and prognostic values were not evaluated in human gastric adenocarcinoma (GAC). Therefore, the present study aimed to investigate the clinico-pathological correlations of LINC00092 and MCM3AP-AS1, LncRNAs expression in GAC, and evaluate their prognostic values.

Materials And Methods: The expression of LINC00092 and MCM3AP-AS1 was detected in 89 GAC tissues by quantitative real-time reverse-transcription PCR (qRT-PCR).

Results: Our results showed that LINC00092 and MCM3AP-AS1 are overexpressed in GAC patients and positively correlated with GAC invasion and vascular, peritoneal, and lymph node metastasis ( < 0.05). Furthermore, the results indicated that MCM3AP-AS1 ( = 0.0225) and LINC00092 ( < 0.001) have positive correlations with GAC patients' overall survival.

Conclusion: Altogether, the present results indicated that LINC00092 and MCM3AP-AS1 overexpression is associated with clinico-pathological characteristic of GAC patients. In addition, both of these LncRNAs may have prognostic value for estimation of patients' overall survival.

References

Wang X, Wang X, Huang G, Chen Y . Lower expression of LINC00092 in lung adenocarcinoma might mean poorer prognosis: A study based on data mining and bioinformatics. Medicine (Baltimore). 2020; 99(44):e23012. PMC: 7598869. DOI: 10.1097/MD.0000000000023012. View

Xu Y, Shao Q, Yao H, Jin Y, Ma Y, Jia L . Overexpression of FOXC1 correlates with poor prognosis in gastric cancer patients. Histopathology. 2013; 64(7):963-70. DOI: 10.1111/his.12347. View

Zhao L, Ji G, Le X, Wang C, Xu L, Feng M . Long Noncoding RNA LINC00092 Acts in Cancer-Associated Fibroblasts to Drive Glycolysis and Progression of Ovarian Cancer. Cancer Res. 2017; 77(6):1369-1382. DOI: 10.1158/0008-5472.CAN-16-1615. View

Chen Z, Zhang H, Wang M, Wang S, Wen Z, Gao Q . Long non-coding RNA Linc00092 inhibits cardiac fibroblast activation by altering glycolysis in an ERK-dependent manner. Cell Signal. 2020; 74:109708. DOI: 10.1016/j.cellsig.2020.109708. View

Riahi A, Hosseinpour-Feizi M, Rajabi A, Akbarzadeh M, Montazeri V, Safaralizadeh R . Overexpression of long non-coding RNA MCM3AP-AS1 in breast cancer tissues compared to adjacent non-tumour tissues. Br J Biomed Sci. 2020; 78(2):53-57. DOI: 10.1080/09674845.2020.1798058. View

Minchenko O, Tsuchihara K, Minchenko D, Bikfalvi A, Esumi H . Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells. World J Gastroenterol. 2014; 20(38):13705-17. PMC: 4194554. DOI: 10.3748/wjg.v20.i38.13705. View

Liu Y, Zhang Z, Wang J, Chen C, Tang X, Zhu J . Metabolic reprogramming results in abnormal glycolysis in gastric cancer: a review. Onco Targets Ther. 2019; 12:1195-1204. PMC: 6389007. DOI: 10.2147/OTT.S189687. View

Rawla P, Barsouk A . Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019; 14(1):26-38. PMC: 6444111. DOI: 10.5114/pg.2018.80001. View

Keyvanloo Shahrestanaki M, Panahi Arasi F, Aghaei M . IPP-1 controls Akt/CREB phosphorylation extension in A adenosine receptor signaling cascade in MIN6 pancreatic β-cell line. Eur J Pharmacol. 2019; 850:88-96. DOI: 10.1016/j.ejphar.2019.02.017. View

10.

Lan L, Liang Z, Zhao Y, Mo Y . LncRNA MCM3AP-AS1 inhibits cell proliferation in cervical squamous cell carcinoma by down-regulating miRNA-93. Biosci Rep. 2020; 40(2). PMC: 7007402. DOI: 10.1042/BSR20193794. View

11.

Abbastabar M, Sarfi M, Golestani A, Khalili E . lncRNA involvement in hepatocellular carcinoma metastasis and prognosis. EXCLI J. 2018; 17:900-913. PMC: 6295623. DOI: 10.17179/excli2018-1541. View

12.

Ho T, Zhou N, Huang J, Koirala P, Xu M, Fung R . Targeting non-coding RNAs with the CRISPR/Cas9 system in human cell lines. Nucleic Acids Res. 2014; 43(3):e17. PMC: 4330338. DOI: 10.1093/nar/gku1198. View

13.

Wang H, Xu T, Wu L, Xu H, Liu R . Molecular mechanisms of MCM3AP-AS1 targeted the regulation of miR-708-5p on cell proliferation and apoptosis in gastric cancer cells. Eur Rev Med Pharmacol Sci. 2020; 24(5):2452-2461. DOI: 10.26355/eurrev_202003_20512. View

14.

Chen Y, Chen Z, Mo J, Pang M, Chen Z, Feng F . Identification of HCG18 and MCM3AP-AS1 That Associate With Bone Metastasis, Poor Prognosis and Increased Abundance of M2 Macrophage Infiltration in Prostate Cancer. Technol Cancer Res Treat. 2021; 20:1533033821990064. PMC: 7897818. DOI: 10.1177/1533033821990064. View

15.

Yoruker E, Keskin M, Kulle C, Holdenrieder S, Gezer U . Diagnostic and prognostic value of circulating lncRNA H19 in gastric cancer. Biomed Rep. 2018; 9(2):181-186. PMC: 6073100. DOI: 10.3892/br.2018.1116. View

16.

Gao S, Zhao Z, Wu R, Zhang Y, Zhang Z . Prognostic value of long noncoding RNAs in gastric cancer: a meta-analysis. Onco Targets Ther. 2018; 11:4877-4891. PMC: 6098423. DOI: 10.2147/OTT.S169823. View

17.

Zhang S, Cao H, Ye L, Wen X, Wang S, Zheng W . Cancer-associated methylated lncRNAs in patients with bladder cancer. Am J Transl Res. 2019; 11(6):3790-3800. PMC: 6614623. View

18.

Sun H, Wu P, Zhang B, Wu X, Chen W . MCM3AP-AS1 promotes cisplatin resistance in gastric cancer cells via the miR-138/FOXC1 axis. Oncol Lett. 2021; 21(3):211. PMC: 7836396. DOI: 10.3892/ol.2021.12472. View

19.

Wong M, Huang J, Chan P, Choi P, Lao X, Chan S . Global Incidence and Mortality of Gastric Cancer, 1980-2018. JAMA Netw Open. 2021; 4(7):e2118457. PMC: 8314143. DOI: 10.1001/jamanetworkopen.2021.18457. View

20.

Zhao C, Li L, Xu J, Li Z, Shi P, Jiang R . LINC00092 Suppresses the Malignant Progression of Breast Invasive Ductal Carcinoma Through Modulating SFRP1 Expression by Sponging miR-1827. Cell Transplant. 2022; 31:9636897221086967. PMC: 8958677. DOI: 10.1177/09636897221086967. View