An In-depth Understanding of the Role and Mechanisms of T Cells in Immune Organ Aging and Age-related Diseases

Overview

Journal Sci China Life Sci

Specialties Biology
Science

Date 2024 Sep 4

PMID 39231902

Authors

Yudai Xu

Zijian Wang

Shumin Li

Jun Su

Lijuan Gao

Junwen Ou

Zhanyi Lin

Oscar Junhong Luo

Chanchan Xiao

Guobing Chen

Affiliations

Soon will be listed here.

Abstract

T cells play a critical and irreplaceable role in maintaining overall health. However, their functions undergo alterations as individuals age. It is of utmost importance to comprehend the specific characteristics of T-cell aging, as this knowledge is crucial for gaining deeper insights into the pathogenesis of aging-related diseases and developing effective therapeutic strategies. In this review, we have thoroughly examined the existing studies on the characteristics of immune organ aging. Furthermore, we elucidated the changes and potential mechanisms that occur in T cells during the aging process. Additionally, we have discussed the latest research advancements pertaining to T-cell aging-related diseases. These findings provide a fresh perspective for the study of T cells in the context of aging.

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