Investigation of Pre and Postoperative Th1/Th2 Cytokine Balance and Novel Cytokines in Colorectal Cancer Patients

Overview

Journal Clin Exp Med

Specialty General Medicine

Date 2024 Sep 4

PMID 39230623

Authors

Emre Gulcek

Yunushan Furkan Aydogdu

Umut Ihsan Emreol

Emin Umit Bagriacik

Nusret Akyurek

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) is a major health problem worldwide and is usually detected in advanced stages, although it is highly treatable with early detection. The aim of this study was to examine the serum levels of various cytokines involved in the pathogenesis of CRC. The study included 29 patients and 30 healthy volunteers. Blood samples were collected twice from the patient group, before and after surgery, and these samples were evaluated for interleukin (IL) 4, 10, 23r, 37, 38, 40 and interferon (IFN) gamma levels. The results showed that IL-4 and IL-38 levels were significantly lower in the preoperative serum samples of the patient group compared to the control group (p < 0.001 and p = 0.01, respectively), while IL-4, IL-10, IL-38 and IL-40 levels increased significantly in the postoperative period (p = 0.004, p = 0.02, p = 0.03 and p = 0.004, respectively). These findings may contribute to the development of immunotherapy agents in the treatment of CRC. However, comprehensive studies on larger patient groups are needed to fully understand the role of cytokines in CRC pathogenesis.

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