HIF1A-AS2 Promotes the Metabolic Reprogramming and Progression of Colorectal Cancer Via MiR-141-3p/FOXC1 Axis

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2024 Sep 3

PMID 39227375

Authors

Xinyang Zhong

Yaxian Wang

Xuefeng He

Xinxin He

Zijuan Hu

Huixia Huang

Jiayu Chen

Keji Chen

Ping Wei

Senlin Zhao

Yilin Wang

Hong Zhang

Bo Feng

Dawei Li

Affiliations

Soon will be listed here.

Abstract

lncRNA can regulate tumorigenesis development and distant metastasis of colorectal cancer (CRC). However, the detailed molecular mechanisms are still largely unknown. Using RNA-sequencing data, RT-qPCR, and FISH assay, we found that HIF1A-AS2 was upregulated in CRC tissues and associated with poor prognosis. Functional experiments were performed to determine the roles of HIF1A-AS2 in tumor progression and we found that HIF1A-AS2 can promote the proliferation, metastasis, and aerobic glycolysis of CRC cells. Mechanistically, HIF1A-AS2 can promote FOXC1 expression by sponging miR-141-3p. SP1 can transcriptionally activate HIF1A-AS2. Further, HIF1A-AS2 can be packaged into exosomes and promote the malignant phenotype of recipient tumor cells. Taken together, we discovered that SP1-induced HIF1A-AS2 can promote the metabolic reprogramming and progression of CRC via miR-141-3p/FOXC1 axis. HIF1A-AS2 is a promising diagnostic marker and treatment target in CRC.

Citing Articles

Exploring the Link Between Noncoding RNAs and Glycolysis in Colorectal Cancer.

Xu L, Shen Y, Zhang C, Shi T, Sheng X J Cell Mol Med. 2025; 29(4):e70443.

PMID: 39993964 PMC: 11850098. DOI: 10.1111/jcmm.70443.

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