A Comparison of White-to-white Measurements Obtained by Anterion AS-OCT Versus Three Optical Devices in Refractive Surgery Candidates

Background And Objectives: To assess the agreement between Anterion AS-OCT and three optical devices in measuring the white-to-white (WTW) diameter in candidates for refractive surgery.

Methods: In this cross-sectional prospective study, 129 right eyes of 129 normal individuals underwent consecutive scans with the Anterion, the Pentacam AXL, the IOLMaster 700, and the Orbscan IIz. Mean difference (MD), 95% limits of agreement (LoA), and concordance correlation coefficient (CCC) were calculated to assess agreement and interchangeability.

Results: The mean age of participants was 30.4 ± 5.9 (range: 21-47) years. The mean WTW distance measured by the different instruments was as follows: 12.00 ± 0.42 mm (range, 10.57 to 13.05) using the Anterion, 11.87 ± 0.34 (11.10 to 12.80) using the Pentacam, 12.12 ± 0.44 (11.00 to 13.30) using the IOLMaster, and 11.73 ± 0.37 (11.00 to 13.10) using the Orbscan. The MD and 95% LoA for Anterion vs. Pentacam, IOLMaster, or Orbscan were [0.11; -0.31 to 0.54 mm], [-0.13; -0.93 to 0.66], and [0.25; -0.28 to 0.78], respectively. The corresponding CCCs were 0.803, 0.514, and 0.631.

Conclusions: This study found weak agreement between Anterion and Pentacam AXL, IOLMaster 700, and Orbscan IIz devices regarding WTW distance measurements in refractive surgery candidates. Therefore, it is not recommended to use Anterion's WTW measurements interchangeably with the other three devices, particularly for phakic intraocular lens sizing.